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Unusual depolymerization mechanism of Poly(ethylene terephthalate) by hydrolase 202.
Chemosphere
January 2025
Environment Research Institute, Shandong University, Qingdao, 266237, PR China.
Polyethylene terephthalate (PET) waste significantly contributes to the global plastic crisis, but enzymatic conversion has become an efficient and environmentally friendly strategy to combat it. Therefore, this study explored the Re-face selective depolymerization mechanisms of a novel PET-degradation peptidase, hydrolase 202. Theoretical calculations revealed that the first step, a catalytic triad-assisted nucleophilic attack, is the rate-determining step.
View Article and Find Full Text PDFUnusual Management of a Rare Case of Methimazole-Resistant Graves Disease.
JCEM Case Rep
January 2025
Baylor University Medical Center, Dallas, TX 75246, USA.
Article Synopsis
- Graves disease (GD) is the main cause of hyperthyroidism but often shows different symptoms like tachycardia and weight loss instead of the typical signs.
- Treatment options include antithyroid drugs (ATDs), radioactive iodine (RAI), and surgery, each with notable side effects and potential complications such as ATD resistance.
- A complex case study of a 58-year-old woman with MMI-resistant GD illustrates the difficulties in treatment, leading to successful management with RAI therapy after unsuccessful attempts with high doses of MMI.
An unusual family of bifunctional terpene synthases has been discovered in which both catalytic domains - a prenyltransferase and a cyclase - are connected by a long, flexible linker. These enzymes are unique to fungi and catalyze the first committed steps in the biosynthesis of complex terpenoid natural products: the prenyltransferase assembles 5-carbon precursors to form C geranylgeranyl diphosphate (GGPP), and the cyclase converts GGPP into a polycyclic hydrocarbon product. Weak domain-domain interactions as well as linker flexibility render these enzymes refractory to crystallization and challenge their visualization by cryo-EM.
View Article and Find Full Text PDFSudden vision loss in pregnancy: Wernicke's encephalopathy in a patient with hyperemesis gravidarum.
BMJ Case Rep
December 2024
Ophthalmology, Kasturba Medical College Mangalore, Mangalore, Karnataka, India.
Wernicke's encephalopathy, the acute phase of Wernicke-Korsakoff syndrome, is characterised as a triad of altered mental status, ocular signs and ataxia. Our patient presented with hyperemesis gravidarum, which is a rare aetiology of Wernicke's encephalopathy. The patient did not have any oculomotor abnormalities, which are more common and classically described in Wernicke's triad.
View Article and Find Full Text PDF[Superficial angiomyxoma in the scrotum].
Medicina (B Aires)
December 2024
Servicio de Patología, Hospital Interzonal General de Agudos Gral. San Martín, La Plata, Buenos Aires, Argentina.
Superficial angiomyxoma is a benign neoplasm of mesenchymal origin that affects both sexes with a slight predilection for males. It can present in a solitary or multiple form, within the framework of the Carney complex, an autosomal dominant syndrome characterized by the triad: cutaneous and cardiac myxomas, skin pigmentation and endocrine overactivity. They occur more commonly in the head and neck, trunk and lower limbs; the location in the genital region and particularly in the scrotum is very unusual.
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