AI Article Synopsis
- The study aimed to investigate the prevalence of occult hepatitis B virus (OBI) in a group of mothers and their teenage children, focusing on HBV S gene variations.
- Researchers followed up with 102 mother-teen pairs after collecting questionnaires and blood samples to detect HBV infection levels using various methods like ELISA and PCR.
- Results showed a higher prevalence of OBI in mothers (10%) compared to teenagers (2%), and different genotypes were identified, with a notable proportion of genotype-C strains present in occult HBV cases.
Article Abstract
Objective: Prevalence of occult hepatitis B virus (HBV) infection (OBI) was investigated in a paired mother-teenager population and HBV S gene variation including overt and occult HBV, was determined.
Methods: A follow-up study based on an initial survey of 135 mother-teenager pairs was carried out through collection of questionnaires and blood samples HBsAg were detected by ELISA method, viral load by PCR amplification and HBV S gene by phylogenetic analysis.
Results: 102 pairs of subjects were followed-up. Blood samples from 94 mothers and 101 children were collected. OBI prevalence in mothers was 10.0% (6/60), significantly higher than 2.0% (2/101) in teenagers. Medians of viral load were 399.9 IU/ml and 247.6 IU/ml in overt and occult HBV strains, but without significant difference. 1 occult HBV strain belonged to genotype B with serotype adw while the other 7 were genotype C with serotype adr. 15 of the overt HBV strains belonged to genotype B with serotype adw and the other 8 were genotype C with serotype adr. Proportions of genotype-C strains were significantly higher in occult HBV strains than in overt HBV strains.
Conclusion: OBI was seen in teenage-mother population.
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