AI Article Synopsis
- The leaves of Cupressus lusitanica Mill. are traditionally used for medicinal purposes in Cameroon, and this study analyzes their essential oil for antimicrobial properties.
- The essential oil was extracted, analyzed for chemical composition, and tested against various bacterial and fungal species, revealing that it contains 49 compounds, with germacrene D being the most abundant.
- Strong antimicrobial activity was observed against certain pathogens, but there are concerns regarding its toxicity, indicating it should be used cautiously despite its potential benefits in treating conditions like whooping cough and skin infections.
Article Abstract
Background: The leaves of Cupressus lusitanica Mill. are used in the western highlands of Cameroon for their medicinal property.
Methods: The leaves of this species were collected in the West Region of Cameroon in August 2010 and subjected to hydrodistillation to obtain the essential oil. The oil was fractionated using adsorption column chromatography. The chemical composition of this oil and its fractions was analysed by gas chromatography-mass spectrometry (GC-MS). The essential oil and fractions were tested for antimicrobial activity against eight bacterial species and six species of Candida by the agar diffusion method. Macrodilution method was used to determine the minimum inhibition concentrations (MICs) and minimum bactericidal and/or fungicidal concentrations (MBCs and MFCs). The toxicity profile of the oil was studied using Swiss mice and Wistar albino rats.
Results: Forty-nine compounds were identified in the essential oil. The main components were germacrene D (18.5%), epi-zonarene (8.2%), cis-calamenene (8.2%), terpinen-4-ol (6.3%), linalool (6.0%) and umbellulone (6.0%). Enterococcus faecalis, Proteus mirabilis and Candida albicans were most susceptible to the oil (MICs of 1.25 and 0.16% for bacteria and fungi respectively). The estimated oral LD50 was 6.33 g/kg. There was an increase in sera ALT and AST activities while the blood cells and protein levels decreased in treated animals.
Conclusion: The results obtained from this study support the ethnomedicinal use of C. lusitanica leaf oil in the treatment of whooping cough and skin infections though it should be used with care. This plant oil could be useful in the standardisation of phytomedicine.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687683 | PMC |
| http://dx.doi.org/10.1186/1472-6882-13-130 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Bergapten Ameliorates Renal Fibrosis by Inhibiting Ferroptosis.
Phytother Res
January 2025
Laboratory of Immunology and Inflammation, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, China.
Renal fibrosis is the most common pathway for the development of end-stage renal disease (ESRD) in various kidney diseases. Currently, the treatment options for renal fibrosis are limited. Ferroptosis is iron-mediated lipid peroxidation, triggered mainly by iron deposition and ROS generation.
View Article and Find Full Text PDFEvaluation of the anti-spasmodic activity of essential oils of fruits and its main chemical component "perillaldehyde" on intestinal smooth muscle contractions of rodents: and approaches.
Front Chem
December 2024
Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, Oujda, Morocco.
Ethnopharmacological Relevance: In Moroccan traditional medicine, plants from the Apiaceae family are widely utilized in folk medicine to treat various diseases associated with the digestive system. plays an important role as an antispasmodic that has been traditionally used, especially to treat digestive tract diseases in children.
Aim Of The Study: The aim of this research was to verify the traditional use by assessing the relaxant and spasmolytic activities of essential oil (ALEO) and then comparing them to the effects and potency of the major constituent of ALEO, which is perillaldehyde.
Constructing age-structured matrix population models for all fishes.
PeerJ
January 2025
Department of Ecology and Conservation Biology, Texas A&M University, College Station, TX, United States of America.
Matrix population models are essential tools in conservation biology, offering key metrics to guide species management and conservation planning. However, the development of these models is often limited by insufficient life history data, particularly for non-charismatic species. This study addresses this gap by using life history data from FishBase and the FishLife R package, complemented by size-dependent natural mortality estimates, to parameterize age-structured matrix population models applicable to most fish species.
View Article and Find Full Text PDFPhytochemical Screening, Antibacterial Activity, and Toxicity of Leaf Extracts.
Prev Nutr Food Sci
December 2024
Toxicology and Environmental Research Group-BIOTOXAM, Faculty of Medicine, Universidad de Cartagena, Cartagena 130015, Colombia.
In Colombia, there is a long tradition of using bijao () leaves to package or wrap various foods. However, scientific studies on are limited, and research to evaluate its toxicity and/or antibacterial activity has not yet been conducted. The objective of this research, therefore, was to evaluate the content of phytochemical compounds, levels of toxicity, and antibacterial activity of the extracts, fractions, and essential oil derived from leaves.
View Article and Find Full Text PDFCharacterization and Biofilm Inhibition of Multidrug-Resistant Isolates.
Int J Microbiol
December 2024
Department of Microbiology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.
Article Synopsis
- The study focused on analyzing multidrug-resistant (MDR) isolates for their ability to form biofilms and the presence of associated genes at a hospital in Nepal.
- A significant majority of the isolates were found to be strong biofilm producers, with 195 out of 200 being MDR and 192 capable of biofilm formation.
- Cinnamaldehyde was the most effective compound in inhibiting biofilm formation, with essential oils and Tween 80 also showing high efficacy, providing insights for potential treatment options against these resistant strains.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!