AI Article Synopsis
- - Metallo-beta-lactamases (MBLs) enable bacteria like Pseudomonas aeruginosa to resist broad-spectrum antibiotics, including carbapenems; a study focused on 122 resistant isolates from two Portuguese hospitals revealed a significant presence of the blaVIM-2 gene in 20.5% of samples.
- - While clonal diversity was noted within each hospital, no transfer of resistant strains occurred between the two hospitals, highlighting localized outbreaks rather than a widespread epidemic.
- - Some isolates (44%) with the blaVIM-2 gene also had class 1 integrons, which might facilitate gene transfer, stressing the need for ongoing screening and monitoring to control the spread of this antibiotic resistance.
Article Abstract
Metallo-beta-lactamases (MBLs) can confer broad-spectrum beta-lactam resistance, including carbapenems. The aim of this work was to document the occurrence of MBLs in 122 imipenem-resistant Pseudomonas aeruginosa isolates collected in two Portuguese central hospitals, to determine their antimicrobial susceptibility, and to observe if there were intra- and interhospital epidemic spread. About 20.5% of these isolates presented blaVIM-2, which was found to be widespread in both hospitals. Clonal diversity was observed within hospitals, and no interhospital spread was observed. Ten of the blaVIM-2-positive isolates (44%), from both hospitals, presented one or two class 1 integrons. Two of those contained a VIM-2 gene, one from each hospital, which is indicative for the possibility of MBL gene transfer. No interhospital spread of integrons was observed. Regular screening and surveillance is needed to prevent spread of this worrisome resistance determinant.
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| http://dx.doi.org/10.1089/mdr.2013.0029 | DOI Listing |
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