The purpose of this study was to evaluate the prognostic value of the Palliative Performance Scale (PPSv2) in the palliative care unit of our hospital, which sees more than 1500 referrals a year (both inpatient and outpatient). We evaluated 356 admission episodes into our department, focusing mainly on patients with advanced cancer. The PPS has been shown to be useful in prognostication and this study confirms this in a fairly large study population in a tertiary care, teaching hospital. We further evaluated the impact of certain biologic variables in survival length, and eventually looked at variables significant for survival at 90 days, developing a prognostic model incorporating these variables. We believe that the study results will aid health care professionals in assessing survival length of their patients more accurately, thus helping to guide decisions for treatment and care in a more judicious manner. It will also allow us to choose patients most likely to benefit from hospice resources.
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http://dx.doi.org/10.1089/jpm.2012.0556 | DOI Listing |
J Pathol Clin Res
January 2025
Department of Urology, University of Duisburg-Essen, Essen, Germany.
Distinct molecular subtypes of muscle-invasive bladder cancer (MIBC) may show different platinum sensitivities. Currently available data were mostly generated at transcriptome level and have limited comparability to each other. We aimed to determine the platinum sensitivity of molecular subtypes by using the protein expression-based Lund Taxonomy.
View Article and Find Full Text PDFCureus
January 2025
Anesthesiology and Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, NLD.
When a difficult airway is anticipated, awake tracheal intubation can be considered. Usually, low doses of sedatives are administered during this procedure for minimal sedation and anxiolysis, such as midazolam and remifentanil. The newly developed ultra-short-acting benzodiazepine remimazolam has a pharmacokinetic profile that is more suitable for titration during awake tracheal intubation than the long-acting midazolam.
View Article and Find Full Text PDFNarra J
December 2024
Division of Psychosomatic and Palliative, Department of Internal Medicine, Faculty of Medicine, Universitas Udayana, Bali, Indonesia.
The incidence of psychosomatic disorders is increasing in Indonesia, and therefore screening instruments that are culturally appropriate for the Indonesian population are needed. The aim of this study was to assess the validity and reliability of the Shatri Sinulingga psychosomatic test (SSPT) questionnaire as a screening instrument for psychosomatic disorders in Indonesia. An analytic descriptive cross-sectional study divided into two stages (questionnaire formulation and distribution through the Psikosom.
View Article and Find Full Text PDFAcad Emerg Med
January 2025
Department of Emergency Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Objectives: Identifying patients in the emergency department (ED) at higher risk for in-hospital mortality can inform shared decision making and goals-of-care discussions. Electronic health record systems allow for integrated multivariable logistic regression (LR) modeling, which can provide early predictions of mortality risk in time for crucial decision making during a patient's initial care. Many commonly used LR models require blood gas analysis values, which are not frequently obtained in the ED.
View Article and Find Full Text PDFJMIR Res Protoc
January 2025
Brain Injury Research Center, Department of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Background: Alzheimer disease and related dementias (ADRDs) are increasingly common progressive conditions that have a substantial impact on individuals and their primary care partners-together described as a dyad. The stressors experienced by dyad members at around the time of ADRD diagnosis commonly produce clinically elevated emotional distress (ie, depression and anxiety symptoms), which can become chronic and negatively impact health, relationships, and the overall quality of life. Dyads commonly report unmet needs for early support to address these challenges early after diagnosis.
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