AI Article Synopsis
- The study aimed to assess the oxidative status in children experiencing simple febrile seizures after a seizure incident.
- Researchers compared 32 children who had experienced a seizure due to a respiratory infection with 30 healthy controls, measuring oxidant and antioxidant levels in their blood.
- Results indicated that children with febrile seizures had significantly higher total oxidant levels and lower antioxidant levels, suggesting increased oxidative stress may elevate the risk of future seizures.
Article Abstract
Objective: To evaluate the oxidative status following a seizure in children experiencing a simple febrile seizure.
Methods: The cross-sectional study was conducted at Harran University, Turkey, between January and September 2011. It comprised 32 paediatric patients who, within the preceding 8 hours, had experienced a seizure due to upper respiratory tract infection and had been diagnosed with simple febrile seizure, and 30 healthy children as the control group. Blood was taken from the patients 8 hours after the seizure. Total oxidant level and Total anti-oxidant level were measured according to the Erel technique and the oxidative stress index was calculated. Data was analysed using SPSS 11.5.
Results: The mean values of the total oxidant level and the oxidative stress index of the cases were found to be significantly high compared to the controls and the total anti-oxidant level was found to be significantly low (p < 0.01, p < 0.01, p < 0.03 respectively).
Conclusion: The increased total oxidant level and decreased total anti-oxidant level resulting in increased oxidative stress associated with febrile seizure patients may increase the risk of experiencing febrile seizures.
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