AI Article Synopsis
- The study introduces a method for creating linear assemblies of short DNA duplexes using β-cyclodextrin and adamantane.
- The assembled DNA duplexes showed higher melting temperatures (Tm) than natural DNA hybrids, indicating better stability.
- Competition tests with other molecules revealed that binding external guests could significantly decrease the melting temperature of these modified duplexes, supporting the potential for complex formation between different duplexes.
Article Abstract
We propose linear end-to-end assemblies of short DNA duplexes based on β-cyclodextrin-adamantane complexation. The assembled duplexes exhibited increased Tm values compared with those of the corresponding natural hybrids. Competition experiments with external guest molecules showed a substantial decrease in Tm of the terminal modified duplexes, suggesting the viability of inter-duplex complexation.
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| http://dx.doi.org/10.1039/c3cc43109f | DOI Listing |
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