Considering the important role that surface waters serve for drinking water production, it is important to know if these resources are under the impact of contaminants. Apart from environmental pollutants such as pesticides, compounds such as (xeno)estrogens have received al lot of research attention and several large monitoring campaigns have been carried out to assess estrogenic contamination in the aquatic environment. The introduction of novel in vitro bioassays enables researchers to study if - and to what extent - water bodies are under the impact of less-studied (synthetic) hormone active compounds. The aim of the present study was to carry out an assessment on the presence and extent of glucocorticogenic activity in Dutch surface waters that serve as sources for drinking water production. The results show glucocorticogenic activity in the range of
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http://dx.doi.org/10.1016/j.chemosphere.2013.04.091 DOI Listing Publication Analysis
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Environ Int
December 2022
Department of Effect-Directed Analysis, UFZ - Helmholtz Centre for Environmental Research, Leipzig, Germany; Department of Evolutionary Ecology and Environmental Toxicology, Goethe University, Frankfurt am Main, Germany.
In the present study on endocrine disrupting chemicals (EDCs) in treated wastewater, we used chemical and effect-based tools to analyse 56 wastewater treatment plant (WWTP) effluents from 15 European countries. The main objectives were (i) to compare three different receptor-based estrogenicity assays (ERα-GeneBLAzer, p-YES, ERα-CALUX®), and (ii) to investigate a combined approach of chemical target analysis and receptor-based testing for estrogenicity, glucocorticogenic activity, androgenicity and progestagenic activity (ERα-, GR-, AR- and PR-GeneBLAzer assays, respectively) in treated wastewater. A total of 56 steroids and phenols were detected at concentrations ranging from 25 pg/L (estriol, E3) up to 2.
View Article and Find Full Text PDFEnviron Toxicol Chem
January 2021
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA.
PLoS One
August 2020
Division of General Internal Medicine and Institute of Human Genetics, Department of Medicine, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, United States of America.
Racial and ethnic minorities are at higher risk for a variety of diseases. While sociodemographic and lifestyle factors contribute to racial/ethnic health disparities, the biological processes underlying these associations remain poorly understood. Stress and its biological consequences through the glucocorticoid receptor (GR) have been hypothesized to mediate adverse disease outcomes.
View Article and Find Full Text PDFEnviron Pollut
February 2019
RWTH Aachen University, Institute for Environmental Research, Department of Ecosystem Analysis, Aachen, Germany; Nanjing University, State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing, China; Tongji University, College of Environmental Science and Engineering and State Key Laboratory of Pollution Control and Resource Reuse, Shanghai, China.
Cyanobacterial blooms are of global concern due to the multiple harmful risks they pose towards aquatic ecosystem and human health. However, information on the fate of organic pollutants mediated by cyanobacterial blooms in eutrophic water remains elusive. In the present study, endocrine disruptive potentials of phytoplankton samples were evaluated throughout a year-long surveillance in a large and eutrophic freshwater lake.
View Article and Find Full Text PDFSci Total Environ
February 2019
RWTH Aachen University, Institute for Environmental Research, Department of Ecosystem Analysis, Aachen, Germany; Research Institute for Ecosystem Analysis and Assessment - gaiac, Aachen, Germany; Tongji University, College of Environmental Science and Engineering, State Key Laboratory of Pollution Control and Resource Reuse, Shanghai, China; Nanjing University, State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing, China. Electronic address:
In the present study, both bioanalytical and instrumental tools were employed to examine the endocrine-disruptive potentials of water samples, cyanobloom samples, and sediment samples collected from in the northern region of Taihu Lake (China) during cyanobloom season. Results from cell-based bioassays suggested the occurrence of estrogenic, anti-estrogenic, anti-androgenic, and anti-glucocorticogenic activities, while no androgenic and glucocorticogenic activities were observed in the collected samples. Using an UPLC-MS/MS system, 29 endocrine disrupting compounds including seven estrogens, seven androgens, six progestogens, and five adrenocortical hormones and four industrial pollutants were simultaneously detected.
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