Considering the important role that surface waters serve for drinking water production, it is important to know if these resources are under the impact of contaminants. Apart from environmental pollutants such as pesticides, compounds such as (xeno)estrogens have received al lot of research attention and several large monitoring campaigns have been carried out to assess estrogenic contamination in the aquatic environment. The introduction of novel in vitro bioassays enables researchers to study if - and to what extent - water bodies are under the impact of less-studied (synthetic) hormone active compounds. The aim of the present study was to carry out an assessment on the presence and extent of glucocorticogenic activity in Dutch surface waters that serve as sources for drinking water production. The results show glucocorticogenic activity in the range of

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2013.04.091DOI Listing

Publication Analysis

Top Keywords

glucocorticogenic activity
12
surface waters
12
waters serve
8
drinking water
8
water production
8
occurrence glucocorticogenic
4
activity surface
4
waters netherlands
4
netherlands considering
4
considering role
4

Similar Publications

Endocrine disrupting chemicals entering European rivers: Occurrence and adverse mixture effects in treated wastewater.

Environ Int

December 2022

Department of Effect-Directed Analysis, UFZ - Helmholtz Centre for Environmental Research, Leipzig, Germany; Department of Evolutionary Ecology and Environmental Toxicology, Goethe University, Frankfurt am Main, Germany.

In the present study on endocrine disrupting chemicals (EDCs) in treated wastewater, we used chemical and effect-based tools to analyse 56 wastewater treatment plant (WWTP) effluents from 15 European countries. The main objectives were (i) to compare three different receptor-based estrogenicity assays (ERα-GeneBLAzer, p-YES, ERα-CALUX®), and (ii) to investigate a combined approach of chemical target analysis and receptor-based testing for estrogenicity, glucocorticogenic activity, androgenicity and progestagenic activity (ERα-, GR-, AR- and PR-GeneBLAzer assays, respectively) in treated wastewater. A total of 56 steroids and phenols were detected at concentrations ranging from 25 pg/L (estriol, E3) up to 2.

View Article and Find Full Text PDF
Article Synopsis
  • Glucocorticoids are steroid hormones that influence many body functions and their effects may be disrupted by certain environmental chemicals that interfere with their receptors, posing risks to health.
  • Researchers created a cell-based bioassay using breast cancer cells to measure the glucocorticogenic activity (TGA) of various environmental chemicals and human serum effectively.
  • The bioassay demonstrated specificity for glucocorticoids, showing a significant response to dexamethasone and identifying three chemicals that enhanced cortisol receptor activity; it offers a new tool for evaluating the impact of these chemicals on glucocorticoid signaling.
View Article and Find Full Text PDF

Plasma glucocorticogenic activity, race/ethnicity and alcohol intake among San Francisco Bay Area women.

PLoS One

August 2020

Division of General Internal Medicine and Institute of Human Genetics, Department of Medicine, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, United States of America.

Racial and ethnic minorities are at higher risk for a variety of diseases. While sociodemographic and lifestyle factors contribute to racial/ethnic health disparities, the biological processes underlying these associations remain poorly understood. Stress and its biological consequences through the glucocorticoid receptor (GR) have been hypothesized to mediate adverse disease outcomes.

View Article and Find Full Text PDF

Cyanobacterial blooms act as sink and source of endocrine disruptors in the third largest freshwater lake in China.

Environ Pollut

February 2019

RWTH Aachen University, Institute for Environmental Research, Department of Ecosystem Analysis, Aachen, Germany; Nanjing University, State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing, China; Tongji University, College of Environmental Science and Engineering and State Key Laboratory of Pollution Control and Resource Reuse, Shanghai, China.

Cyanobacterial blooms are of global concern due to the multiple harmful risks they pose towards aquatic ecosystem and human health. However, information on the fate of organic pollutants mediated by cyanobacterial blooms in eutrophic water remains elusive. In the present study, endocrine disruptive potentials of phytoplankton samples were evaluated throughout a year-long surveillance in a large and eutrophic freshwater lake.

View Article and Find Full Text PDF

Effect-based and chemical analyses of agonistic and antagonistic endocrine disruptors in multiple matrices of eutrophic freshwaters.

Sci Total Environ

February 2019

RWTH Aachen University, Institute for Environmental Research, Department of Ecosystem Analysis, Aachen, Germany; Research Institute for Ecosystem Analysis and Assessment - gaiac, Aachen, Germany; Tongji University, College of Environmental Science and Engineering, State Key Laboratory of Pollution Control and Resource Reuse, Shanghai, China; Nanjing University, State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing, China. Electronic address:

In the present study, both bioanalytical and instrumental tools were employed to examine the endocrine-disruptive potentials of water samples, cyanobloom samples, and sediment samples collected from in the northern region of Taihu Lake (China) during cyanobloom season. Results from cell-based bioassays suggested the occurrence of estrogenic, anti-estrogenic, anti-androgenic, and anti-glucocorticogenic activities, while no androgenic and glucocorticogenic activities were observed in the collected samples. Using an UPLC-MS/MS system, 29 endocrine disrupting compounds including seven estrogens, seven androgens, six progestogens, and five adrenocortical hormones and four industrial pollutants were simultaneously detected.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!