Four new abietane diterpenoids (1-4), a new 9(10→20)-abeo-abietane diterpenoid (5), and a new sesquiterpene pyridine alkaloid (6) were isolated from the roots of Euonymus lutchuensis along with 19 known compounds. The structures of the new compounds were elucidated by interpretation of the spectroscopic data.
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http://dx.doi.org/10.1021/np400110g | DOI Listing |
Int J Mol Sci
December 2024
Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, Shaanxi Normal University, Xi'an 710062, China.
Danshen ( Bunge) is a perennial herbaceous plant of the Salvia genus in the family Lamiaceae. Its dry root is one of the important traditional Chinese herbal medicines with a long officinal history. The yield and quality of are influenced by various factors, among which drought is one of the most significant types of abiotic stress.
View Article and Find Full Text PDFPhytochemistry
December 2024
Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, Jiangxi, 341000, China; Jiangxi Provincal Key Laboratory of Tissue Engineering, 2024SSY06291, Gannan Medical University, Ganzhou, Jiangxi, 341000, China; School of Pharmacy, Nanchang Medical College, Nanchang, Jiangxi, 330052, China. Electronic address:
Thirteen abietane-type diterpenoids, including seven previously undescribed compounds and six known analogs, were isolated from the root and aerial parts of Phlegmariurus carinatus. Their structures were elucidated by comprehensive spectroscopic data analysis (UV, IR, NMR, and HRESIMS) and quantum chemical calculations (calculated ECD or C NMR). Notably, these compounds exhibited high structural diversity.
View Article and Find Full Text PDFRen Fail
December 2024
Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Background: Renal fibrosis, a hallmark of chronic kidney disease, is closely associated with dysregulated gluconeogenesis. Tanshinone I (Tan I), a bioactive compound derived from the traditional Chinese medicine Danshen, exhibits antifibrotic and anti-inflammatory properties. However, its effects on gluconeogenesis and the mechanisms through which it alleviates renal fibrosis remain unclear.
View Article and Find Full Text PDFCurr Mol Pharmacol
December 2024
Narula Research, LLC, 107 Boulder Bluff, Chapel Hill, NC27516, USA.
Introduction: Autism is a neurodevelopmental disorder associated with mitochondrial dysfunction, apoptosis, and neuroinflammation. These factors can lead to the overactivation of c-JNK and p38MAPK.
Methods: In rats, stereotactic intracerebroventricular (ICV) injection of propionic acid (PPA) results in autistic-like characteristics such as poor social interaction, repetitive behaviours, and restricted communication.
J Nat Prod
December 2024
Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand.
Six new abietane diterpenes, roscoeananes A-F (-), along with two known compounds (-) were isolated from the rhizomes of . The structures of all compounds were elucidated by analysis of spectroscopic data, and the absolute configurations were assigned by a comparison of the theoretical and experimental electronic circular dichroism (ECD) spectra and a comparison with literature values. The unreported compound is an ether-linked dimer of roscoeanane B ().
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