AI Article Synopsis
- The study investigates how cisplatin affects hair cells in different parts of the cochlea by comparing drug concentrations in the base and apex.
- Ten to 240 minutes following cisplatin injection in guinea pigs, researchers measured drug levels in various fluids, finding higher concentrations in the cochlear base shortly after administration.
- The results suggest that the higher initial concentration of cisplatin in the cochlear base could be linked to the toxicity and loss of outer hair cells observed in that area.
Article Abstract
Objectives/hypothesis: Cisplatin produces toxic lesions to outer hair cells (OHCs) in the cochlear base but not in the apex. The objective of this study was to compare the pharmacokinetic profile of cisplatin in scala tympani (ST) perilymph in the cochlear base and apex, respectively.
Study Design: In vivo animal study.
Methods: Forty-seven guinea pigs were given an intravenous bolus injection of an ototoxic dose of cisplatin. Ten to 240 minutes after cisplatin was given, blood, cerebrospinal fluid (CSF), and ST perilymph were aspirated within the same target time. ST perilymph was aspirated from the basal turn and from the apex of the cochlea by two different sampling techniques. Liquid chromatography with postcolumn derivatization was used for quantitative determination of the parent drug.
Results: Ten minutes after administration, the concentration of cisplatin in ST perilymph was 4-fold higher in the basal turn of the cochlea than in the apex. At 30 minutes, the drug concentrations did not differ. At 60 minutes, the level of cisplatin in ST perilymph and blood UF was equivalent. The perilymph-blood ratio increased thereafter with time.
Conclusion: The pharmacokinetic findings of an early high concentration of cisplatin in the base of the cochlea and delayed elimination of cisplatin from ST perilymph compared to blood might correlate to the cisplatin-induced loss of OHCs in the base of the cochlea.
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| http://dx.doi.org/10.1002/lary.24235 | DOI Listing |
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