AI Article Synopsis
- SOX10 is a crucial transcription factor for the development and maintenance of neural crest cells, which are important for various cell types in the body.
- It is frequently found in certain tumors, particularly melanomas and some salivary gland neoplasms, indicating its role in tumor biology.
- Due to its specific expression pattern, SOX10 serves as an important immunohistochemical marker in surgical pathology, aiding in cancer diagnosis.
Article Abstract
SOX10 is a transcription factor that is essential for the generation of neural crest cells, their survival, and maintenance of pluripotency. Recent studies have shown that, among tumors, SOX10 is commonly expressed in melanomas, including desmoplastic melanomas, tumors with Schwann cell differentiation, and some salivary gland neoplasms, particularly those with myoepithelial differentiation. Because of its restricted expression, SOX10 has proved to be a useful immunohistochemical marker with a wide range of diagnostic applications in surgical pathology, some of which are briefly reviewed.
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| http://dx.doi.org/10.1097/PAP.0b013e318297a9d0 | DOI Listing |
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