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The natural product honokiol inhibits calcineurin inhibitor-induced and Ras-mediated tumor promoting pathways. | LitMetric

Although calcineurin inhibitors (CNIs) are very useful in preventing allograft rejection, they can mediate a rapid progression of post-transplantation malignancies. The CNI cyclosporine A (CsA) can promote renal tumor growth through activation of the proto-oncogene ras and over-expression of the angiogenic cytokine VEGF; the ras activation also induces over-expression of the cytoprotective enzyme HO-1, which promotes survival of renal cancer cells. Here, we show that the natural product honokiol significantly inhibited CsA-induced and Ras-mediated survival of renal cancer cells through the down-regulations of VEGF and HO-1. Thus, honokiol treatment may help to prevent tumor-promoting effects of CsA in transplant patients.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750070PMC
http://dx.doi.org/10.1016/j.canlet.2013.05.036DOI Listing

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