Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare central jaw carcinoma derived from odontogenic epithelial remnants. When the tumour arises in an existing cyst, it may be difficult to recognise early PIOSCC and carry out necessary treatment. We report a case diagnosed in a 50-year-old man where timely intervention was delayed and prognosis was affected and the case diagnosed eventually by comprehensive clinical, radiological and histopathological examination.
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http://dx.doi.org/10.1136/bcr-2013-009639 | DOI Listing |
Mol Cell Endocrinol
January 2025
Department of Bone injury of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. Electronic address:
Chemerin, an adipocyte-secreted adipokine, can regulate bone resorption and bone formation and is a promising therapy for postmenopausal osteoporosis. However, the effect of endogenous chemerin on intraosseous vascular remodeling in postmenopausal osteoporosis remains unclear. In this study, we investigated the effect of chemerin on osteogenesis formation and intraosseous vascular remodeling in ovariectomized Rarres2 knockout (Rarres2) mice.
View Article and Find Full Text PDFSemin Diagn Pathol
January 2025
Dept of Oral Pathology, King George's Medical University, Uttar Pradesh, India. Electronic address:
Primary intraosseous carcinoma (PIOC) is a rare and challenging jawbone malignancy often linked to odontogenic cysts. With minimal connection to oral mucosa and a low incidence rate, PIOC presents significant diagnostic difficulties, often mimicking other odontogenic lesions. Histogenesis and the correct classification of the lesion remains debated, with theories suggesting origins from odontogenic epithelium or cysts.
View Article and Find Full Text PDFBMJ Case Rep
January 2025
Radiodiagnosis, AIIMS Nagpur, Nagpur, Maharashtra, India.
A boy in his middle childhood presented with a gradually enlarging, mildly tender swelling in the left frontal region, noticed after minor trauma. Skull radiograph and non-enhanced CT revealed a diffuse sclerotic lesion involving the left frontal bone and overlying subcutaneous soft tissue, suggestive of an intraosseous haemangioma. Contrast-enhanced MRI showed an expansile, hypointense lesion in the frontal bone on the left side with enhancing extraosseous components and a small extra-axial cyst.
View Article and Find Full Text PDFFront Oncol
January 2025
BIOCEV, First Faculty of Medicine, Charles University, Prague, Czechia.
Introduction: Progressing myelodysplastic syndrome (MDS) into acute myeloid leukemia (AML) is an indication for hypomethylating therapy (HMA, 5-Azacytidine (AZA)) and a BCL2 inhibitor (Venetoclax, VEN) for intensive chemotherapy ineligible patients. Mouse models that engraft primary AML samples may further advance VEN + AZA resistance research.
Methods: We generated a set of transplantable murine PDX models from MDS/AML patients who developed resistance to VEN + AZA and compared the differences in hematopoiesis of the PDX models with primary bone marrow samples at the genetic level.
Clin Adv Periodontics
January 2025
Department of Postgraduate Periodontics, Maimónides University, Buenos Aires, Argentina.
Background: There is substantial evidence that smokers present a less favorable response following regenerative periodontal surgery. However, there are no reports to date on the response to regenerative procedures in chronic cannabis smokers. In the present case study, we discuss the periodontal outcomes of reparative and regenerative surgical treatment in a cannabis consumer patient with generalized stage III grade C periodontitis.
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