A total of 424 patients with gastroduodenal ulcers were examined. Spot biopsy specimens of gastroduodenal tissue were examined by histologic and microbiologic methods. Both methods equally frequently detected C. pylori (in 87 +/- 5 and in 85 +/- 6 percent of cases, respectively). C. pylori were more frequently detected during ulcer exacerbation than during remissions. Detection of the agent in smears of smashed mucosal biopsy specimens was found to be a rapid diagnostic method, permitting detection of C. pylori in 90.8 percent of cases. High detection rate of C. pylori in patients with peptic ulcers and chronic gastritis necessitates accurate treatment of endofibroscopes.
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