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TCTP overexpression is associated with the development and progression of glioma. | LitMetric

TCTP overexpression is associated with the development and progression of glioma.

Tumour Biol

Department of Radiation Medicine, Ministry of Education Key Laboratory of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, No. 169, Changle West Road, Xi'an, 710032, China.

Published: December 2013

AI Article Synopsis

  • * High levels of TCTP in glioma are linked to more advanced disease and shorter overall survival for patients, suggesting its significance in disease progression.
  • * The study establishes TCTP expression as an independent prognostic factor for glioma patients, highlighting its potential as a target for diagnosis and treatment.

Article Abstract

Upregulation of translationally controlled tumor protein (TCTP) has been reported in a variety of malignant tumors. However, the impact of TCTP in glioma remains unclear. The objective of this study was to investigate the expression and prognostic value of TCTP in glioma patients. Western blot analysis was used to characterize the expression patterns of TCTP in 45 glioma and 22 normal brain tissues. Immunohistochemistry on a tissue microarray containing 127 cases of glioma was performed to analyze the association between TCTP expression and clinicopathological features. Compared with normal brain tissues, TCTP expression was significantly higher in glioma tissues (p <0.001). In addition, high TCTP expression in glioma was significantly associated with advanced pathological grade (p = 0.018). Kaplan-Meier analysis showed that patients with glioma and higher TCTP expression tend to have shorter overall survival time (p <0.001). In multivariate analysis, TCTP expression was proved to be an independent prognostic factor for patients with glioma (p <0.001). In conclusion, this study confirmed the overexpression of TCTP and its association with tumor progression in glioma. It also provided the first evidence that TCTP expression in glioma was an independent prognostic factor of patients, which might be a potential diagnostic and therapeutic target of glioma.

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Source
http://dx.doi.org/10.1007/s13277-013-0906-9DOI Listing

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