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Congenital and Perinatal Viral Infections: Consequences for the Mother and Fetus.
Viruses
October 2024
Feto Maternal Centre, Al Markhiya Doha, Doha P.O. Box 34181, Qatar.
Viruses are the most common congenital infections in humans and an important cause of foetal malformations, neonatal morbidity, and mortality. The effects of these infections, which are transmitted in utero (transplacentally), during childbirth or in the puerperium depend on the timing of the infections. These vary from miscarriages (usually with infections in very early pregnancy), congenital malformations (when the infections occur during organogenesis) and morbidity (with infections occurring late in pregnancy, during childbirth or after delivery).
View Article and Find Full Text PDFMolecular Biology for Diagnosis of Congenital and Neonatal Infections in the Cerebrospinal Fluid of Newborns from a Brazilian Tertiary Hospital.
Microorganisms
October 2024
Department of Pediatrics, School of Medical Sciences, FCM Unicamp, Campinas 13083-970, SP, Brazil.
Unlabelled: The risk of infection transmission from mother to fetus depends on the pathogen. TORCH agents cause some neuroinfections, including Toxoplasmosis, rubella, Cytomegalovirus, herpes simplex 1 and 2, and others (Varicella Zoster, Parvovirus B-19, Epstein-Barr virus, and Zika virus). The consequences can be stillbirth, prematurity, uterine growth restriction, and congenital malformations.
View Article and Find Full Text PDFMaternal Herpes Zoster Infection Preceding Neonatal Langerhans Cell Histiocytosis: Coincidence or Association?
Cureus
October 2024
Department of Dermatology, Prince Sultan Military Medical City, Riyadh, SAU.
Article Synopsis
- * The exact causes of LCH are not well understood, but they may involve genetic factors, immune system issues, and environmental influences during pregnancy.
- * This report discusses a case of a newborn girl with LCH whose mother had a varicella-zoster infection during pregnancy, hinting at a potential link between prenatal factors and the condition.
Case 334.
Radiology
October 2024
From the Department of Radiology, The Ottawa Hospital-University of Ottawa, 1053 Carling Ave, Ottawa, ON, Canada. K1Y 4E9.
Article Synopsis
- * Her medical history was generally uncomplicated; she denied any recent severe illnesses, risk factors, or travel history, and her vital signs were normal upon examination.
- * Diagnostic tests, including MRI and a lumbar puncture, showed significant findings: abnormalities in the brain, high cerebrospinal fluid pressure, and an elevated white blood cell count in the CSF indicating potential inflammation or infection.
Systematic review on molecular detection of congenital and neonatal infections caused by TORCH and SARS-CoV-2 in newborns' cerebrospinal fluid.
Rev Paul Pediatr
September 2024
Universidade Estadual de Campinas, Campinas, SP, Brazil.
Article Synopsis
- The objective of the review was to verify the advantages of using molecular methods, specifically PCR, for diagnosing congenital infections in the cerebrospinal fluid of newborns.
- The literature search was thorough, utilizing multiple databases and adhering to systematic review guidelines to identify relevant studies published in several languages from August 2021 to December 2022.
- The findings suggest that molecular methods are effective for detecting pathogen genomes, particularly herpes simplex, in newborns suspected of having congenital neuroinfections based on nonspecific initial symptoms.
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