Neonatal transfusion-transmitted hepatitis C virus infection following a pre-seroconversion window-phase donation in Sweden.

Scand J Infect Dis

From the Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg.

Published: October 2013

A 9-day-old child developed a transfusion-transmitted hepatitis C virus (HCV) infection following a pre-seroconversion window-phase donation. Retrospective analysis of donor plasma revealed detectable HCV core antigen (154 fmol/l), as well as HCV RNA (87,000 IU/ml). Of 5.24 million Swedish plasma samples from December 1998 to September 2012, 5 additional window-phase donations were identified.

Download full-text PDF

Source
http://dx.doi.org/10.3109/00365548.2013.797601DOI Listing

Publication Analysis

Top Keywords

transfusion-transmitted hepatitis
8
hepatitis virus
8
infection pre-seroconversion
8
pre-seroconversion window-phase
8
window-phase donation
8
neonatal transfusion-transmitted
4
virus infection
4
donation sweden
4
sweden 9-day-old
4
9-day-old child
4

Similar Publications

Added safety measures coupled with the development and use of pathogen reduction technologies (PRT) significantly reduces the risk of transfusion-transmitted infections (TTIs) from blood products. Current approved PRTs utilize chemical and/or UV-light based inactivation methods. While the effectiveness of these PRTs in reducing pathogens are well documented, these can cause tolerable yet unintended consequences on the quality and efficacy of the transfusion products.

View Article and Find Full Text PDF

Background: Human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) coinfection has emerged as a leading cause of morbidity throughout the world in the last two decades. The coronavirus disease 2019 (COVID-19) pandemic has escalated the disease burden further by increasing the number of intravenous (IV) drug abusers and unemployment.

Aim: The present study was done to analyse the impact of COVID-19 on seroprevalence as well as trends during pre, post and pandemic years of coinfection and mono-infections in the Malwa region of Punjab.

View Article and Find Full Text PDF

Background: Despite saving a vast number of lives through blood transfusions, transfusion-transmitted infections (TTIs) still threaten the lives of people needing blood transfusion. Hence, screening blood donors and reviewing the prevalence of TTIs amongst blood donors might show the impact of these infections among our people. The aim of this study was to evaluate the prevalence rates of transfusion-transmitted infections among blood donors in Makkah as foundation for providing harmless blood transfusion in Makkah, Saudi Arabia.

View Article and Find Full Text PDF

Seroprevalence of Hepatitis B virus surface antigen among African blood donors: a systematic review and meta-analysis.

Front Public Health

November 2024

Department of Community Medicine, Information, and Health Decision Sciences (MEDCIDS), Faculty of Medicine, University of Porto, Porto, Portugal.

Article Synopsis
  • Transfusion Transmitted Infections (TTIs), particularly Hepatitis B (HBsAg), pose a significant public health challenge in Africa, necessitating a review of existing data on blood donors' seroprevalence.
  • A systematic review and meta-analysis of 124 studies, covering over 3.5 million blood donors, revealed a pooled HBsAg prevalence of 6.93%, with regional variances indicating higher rates in Western (10.09%) and Central Africa (7.81%).
  • The analysis identified a decrease in HBsAg prevalence over time, with higher rates in studies published from 2001 to 2010 compared to more recent studies from 2011 to 2024.
View Article and Find Full Text PDF

The hepatitis E virus (HEV) is an emerging infectious disease with zoonotic potential, causing acute hepatitis in humans. Infections in healthy individuals are often acute, self-limiting and asymptomatic, thus leading to the underdiagnosis of HEV infections. Asymptomatic HEV infections pose a problem for blood transfusion safety by increasing the risk for transfusion-transmitted HEV infections.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!