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Rosacea-like skin reaction under treatment with dupilumab for atopic dermatitis.
J Dermatolog Treat
December 2025
Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Purpose: Dupilumab is a widely recommended treatment for moderate-to-severe atopic dermatitis (AD), with known ocular side effects but less frequent cutaneous reactions.
Material And Methods: This case report details a 52-year-old female patient with atopic dermatitis treated with dupilumab. After an initially successful treatment, the patient developed a rosacea-like dermatitis.
Corneal elevation asymmetry vector: Viable predictor of severe one-year-averaged orthokeratology lens decentration.
Cont Lens Anterior Eye
February 2025
Department of Ophthalmology & Clinical Center of Optometry, Peking University People's Hospital, Beijing 100044, China; College of Optometry, Peking University Health Science Center, Beijing, China; Eye Disease and Optometry Institute, Peking University People's Hospital; Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases. Electronic address:
Background: To assess the predictive value of pretreatment corneal elevation asymmetry vector (CEAV) for severe orthokeratology (Ortho-k) lens decentration (LD) in Chinese myopic adolescents.
Methods: A retrospective analysis of 247 myopic participants over one year employed a novel MATLAB algorithm to calculate CEAV and precise LD vector. Subjects were categorized into mild (<1 mm) and severe (≥1 mm) yearly averaged LD (YALD) groups.
Wall-Eyed Internuclear Ophthalmoplegia: History and Hypothesis.
Can J Neurol Sci
November 2024
Neuro-Ophthalmology Section, Division of Neurology, Departments of Medicine, Ophthalmology and Vision Sciences, University Health Network, University of Toronto, Toronto, ON, Canada.
Background: Most patients with internuclear ophthalmoplegia (INO) are orthotropic, although a subset is exotropic. When INO is bilateral, this is termed wall-eyed bilateral internuclear ophthalmoplegia (WEBINO). In 1979, Sharpe described his "first case" of wall-eyed monocular internuclear ophthalmoplegia (WEMINO) as "a unique clinical syndrome" characterized by unilateral INO and ipsilateral exotropia.
View Article and Find Full Text PDFEfficacy of epidermal growth factor in suppressing inflammation and proliferation in pterygial fibroblasts through interactions with microenvironmental M1 macrophages.
Sci Rep
September 2024
Chung-Ang Ocular Surface Restoration via Immune-inflammation Alleviation (CORIA) Laboratory, Seoul, Republic of Korea.
The protein epidermal growth factor (EGF), which plays a crucial role in promoting cell proliferation and survival, has recently demonstrated potential in reducing inflammation. In this study, we examined the impact of EGF on the anti-inflammatory and anti-proliferative properties of pterygium, a prevalent hypervascular proliferative disease affecting the ocular surface. In surgically excised tissues, markers for fibrotic and inflammatory signals, including VIM, ACTA2, FAP, MMP2, VCAM1, ICAM1, CD86, IL6, and IL1B were upregulated in the pterygium body stroma compared to the normal conjunctival stroma.
View Article and Find Full Text PDFOxygen, the Paradox of Life and the Eye.
Front Biosci (Landmark Ed)
September 2024
Department of Biology, University of Pisa, 56123 Pisa, Italy.
Article Synopsis
- Oxidative stress happens when there are too many free radicals (bad molecules) in the body, leading to damage to cells and tissues, which can cause diseases and make us age faster.
- Antioxidants are like superheroes that help protect our bodies from food's damage, but it's important to have a balance because some oxidative stress is necessary for keeping our organs healthy.
- This text talks about finding important research on how oxidative stress affects the eye, showing that while it can cause eye diseases, having some antioxidants can help keep those problems in check.
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