In the title compound, {[Cu(C15H11ClN2O3)(C4H9NO)]n, the Cu(II) cation has square-pyramidal geometry. The morpholine ligand serves as a bridge to link two symmetry-related metal atoms, resulting in an infinite chain structure along the a axis. Adjacent chains are extended into a two-dimensional layered structure via hydrogen bonds formed between morpholine and amide N atoms [N-H···N = 2.971 (3) Å].
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http://dx.doi.org/10.1107/S0108270113011967 | DOI Listing |
Nat Commun
January 2025
Institute of Developmental Biology and Neurobiology, Faculty of Biology, Johannes Gutenberg University Mainz, Mainz, Germany.
After a peripheral nerve injury, Schwann cells (SCs), the myelinating glia of the peripheral nervous system, convert into repair cells that foster axonal regrowth, and then remyelinate or re-ensheath regenerated axons, thereby ensuring functional recovery. The efficiency of this mechanism depends however on the time needed for axons to regrow. Here, we show that ablation of histone deacetylase 8 (HDAC8) in SCs accelerates the regrowth of sensory axons and sensory function recovery.
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December 2024
University of Mainz, Department of Chemistry, Duesbergweg 10-14, 55099 Mainz, Germany.
The title compound CHClN, also named as TRAM-34, crystallizes in the monoclinic space group 2/n. The dihedral angles between the pyrazole ring and the three six-membered rings are 62.28 (9), 69.
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December 2024
University of Mainz, Department of Chemistry, Duesbergweg 10-14, 55099 Mainz, Germany.
The title compound, CHO, was prepared from α-pinene in three steps. The ester and acid moieties are on the slightly folded cyclo-butane ring. In the crystal, carb-oxy-lic acid bound dimers form layers parallel to (202).
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December 2024
Nelson Mandela University, Summerstrand Campus, Department of Chemistry, University Way, Summerstrand, PO Box 77000, Port Elizabeth, 6031, South Africa.
The title compound, CHIN, is the -iodinated derivative of aniline. The asymmetric unit contains two mol-ecules. The structure was refined as a two-component inversion twin with a volume ratio of 55.
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December 2024
EaStCHEM School of Chemistry, University of St Andrews, St Andrews, Fife KY16 9ST, United Kingdom.
In the title compound, CHNO the pyrrolidine ring is almost planar and subtends a dihedral angle of 85.77 (7)° with the pendant phenyl ring. An intra-molecular N-H⋯O hydrogen bond generates an (6) loop.
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