[Polymorphisms of (CAG)n and(GGN)n repeats of androgen receptor gene among ethnic Hui and Han Chinese from Ningxia].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi

Department of Medical Genetics and Cell Biology, Ningxia Medical University, Key Laboratory of Fertility Preservation and Maintenance, Ministry of Education, Key Laboratory of Reproduction and Heredity of Ningxia Hui Autonomous Region, Yinchuan, Ningxia 750004, P.R. China.

Published: June 2013

Objective: To compare the distribution of (CAG)n and (GGN)n repeats polymorphisms of androgen receptor (AR) gene between Hui and Han ethnic Chinese from Ningxia.

Methods: Genotypes of above repeats were determined with DNA sequencing method.

Results: The distribution of (GGN)n repeats was significantly different between the two ethnic groups (P< 0.01), though no such difference was detected with (CAG)n repeats (P> 0.05). Particularly, Han Chinese women carrying 23 GGN repeats were significantly fewer (48.4%) than Hui women (64.7%, P=0.01).

Conclusion: The distribution of GGN repeat is significantly differently among Hui and Han Chinese ethnics from Ningxia.

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2013.03.025DOI Listing

Publication Analysis

Top Keywords

hui han
12
han chinese
12
androgen receptor
8
receptor gene
8
ggnn repeats
8
repeats
6
[polymorphisms cagn
4
cagn andggnn
4
andggnn repeats
4
repeats androgen
4

Similar Publications

The presence of carbapenem-resistant (CR) has become one of the leading causes of life-threatening, hospital-acquired infections globally, especially with a notable prevalence in intensive care units (ICUs). The cross-transmission of microorganisms between patients and the hospital setting is crucial in the development of CR colonization and subsequent infections. Recent studies indicate that colonization typically precedes infection, suggesting the effectiveness and necessity of preventing CR colonization as a primary method to lower infection risks.

View Article and Find Full Text PDF

How to correct QT interval after cardiac resynchronisation therapy.

J Electrocardiol

January 2025

Victorian Heart Institute, Monash University, Clayton, VIC, Australia; Victorian Heart Hospital, Clayton, VIC, Australia. Electronic address:

Introduction: This study evaluates various formulae used to correct the QT interval in patients with wide QRS complexes to calculate corrected QT (QTc) following Cardiac Resynchronisation Therapy (CRT).

Methods: We included patients with severe heart failure and left bundle branch block, presenting with a QRS duration of at least 120 milliseconds, who underwent successful CRT implantation. Patients were excluded if they had non-lateral left ventricular lead placement, metabolic disorders, atrial fibrillation, atrial tachycardia, or high-degree atrioventricular block prior to implantation.

View Article and Find Full Text PDF

SS-31@Fer-1 Alleviates ferroptosis in hypoxia/reoxygenation cardiomyocytes via mitochondrial targeting.

Biomed Pharmacother

January 2025

Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China. Electronic address:

Purpose: Targeting mitochondrial ferroptosis presents a promising strategy for mitigating myocardial ischemia-reperfusion (I/R) injury. This study aims to evaluate the efficacy of the mitochondrial-targeted ferroptosis inhibitor SS-31@Fer-1 (elamipretide@ferrostatin1) in reducing myocardial I/R injury.

Methods: SS-31@Fer-1 was synthesized and applied to H9C2 cells subjected to hypoxia/reoxygenation (H/R) to assess its protective effects.

View Article and Find Full Text PDF

We report the rapid synthesis of primary amides by directly using commercially available ammonia borane (NH·BH), sodium hexamethyldisilazide (NaHMDS), and esters. The success of this protocol relies on NH·BH as the nitrogen source being considerably more convenient and NaHMDS being an excellent proton abstractor but not participating in the nucleophilic addition reaction. The reaction had a wide substrate scope containing bioactive molecules, and most of the substrates were efficiently amidated over 90% yields.

View Article and Find Full Text PDF

Introduction: The mortality rate associated with (MTB) has seen a significant rise in regions heavily affected by the disease over the past few decades. The traditional methods for diagnosing and differentiating tuberculosis (TB) remain thorny issues, particularly in areas with a high TB epidemic and inadequate resources. Processing numerous images can be time-consuming and tedious.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!