AI Article Synopsis
- The study evaluated the neuroprotective effects of silymarin, piracetam, and protocatechuic acid ethyl ester (PCA) on cerebral global ischemic/reperfusion in a rat model.
- The methods included a blockage of blood flow in the carotid arteries for 30 minutes followed by a 24-hour recovery period, during which various neurological and physiological functions were assessed.
- Silymarin and PCA improved cognitive and motor functions, along with reducing brain damage, while piracetam showed some benefits but did not significantly enhance the body's natural defense systems.
Article Abstract
Aims: The neuroprotective activities of silymarin, piracetam and protocatechuic acid ethyl ester (PCA) on cerebral global ischemic/reperfusion were evaluated in a rat model.
Main Methods: A midline ventral incision was made in the throat region. The right and left common carotid arteries were located and a bilateral common carotid artery occlusion (BCCAO) was performed for 30min using atraumatic clamps followed by a 24h period of reperfusion. Neurological/behavioral functions (cognitive and motor), endogenous defense systems (lipid peroxidation, glutathione, catalase, and superoxide dismutase), reduced water content and infarct size and histopathological alterations were then studied.
Key Findings: Silymarin and PCA treatments significantly improved cognitive, motor and endogenous defense functions, histopathological alterations, and, reduced both water content and infarct size compared to the vehicle-treated ischemic control group. Piracetam treatment improved neurological and histopathological alterations, reduced water content and infarct size, but failed to restore/prevent the impaired endogenous defense functions significantly.
Significance: Silymarin showed better neuroprotection than piracetam and PCA in experimentally induced global ischemic/reperfusion and was able to facilitate mnemonic performance.
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| http://dx.doi.org/10.1016/j.lfs.2013.05.020 | DOI Listing |
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