AI Article Synopsis
- The study investigates the link between genetic variations in the estrogen receptor alpha (ERα) gene and breast cancer risk in postmenopausal women with high breast density.
- Researchers observed 308 women aged 45-65, analyzing various factors including family history, lifestyle, and reproductive history.
- Results showed typical genetic distributions and prevalent risk factors like early menarche and obesity, but no significant connections to the ERα polymorphisms.
Article Abstract
Unlabelled: The association of genetic polymorphism in the estrogen receptor alpha (ERα) gene and risk for diseases including breast cancer (BC) has been the subject of great interest.
Objective: Checking on women with high breast density after menopause, the frequency of the Pvull and Xbal polymorphisms of the ERα gene and the correlation between them and the known risk factors for breast cancer.
Method: Observational study with 308 women between 45 and 65 years old with high breast density, without hormonal therapy, menstruation for a year or more, breast and ovarian cancer history. It was characterized in clinical history and physical examination: menarche, menopause, parity, family history of BC, smoking, alcohol intake and body mass index.
Results: The allelic and genotypic frequencies for ERα-Pvull and Xbal: p = 43.99%; p = 56.01%; pp = 32.14%; Pp = 47.73% and PP = 20.13%; X = 41.56%; x = 58.44%; xx = 33.44%; Xx = 50.00% and XX = 16.56%, respectively. The most frequent risk factors for BC: menarche before 12 years old (35.38%), nulliparity or first child after 28 years old (41.66%), family history of BC (19.16%) and overweight/obesity (62.01%).
Conclusion: Allelic and genotypic distribution similar to literature. The risk factors for BC were more prevalent in women with high breast density but without significant associations with these polymorphisms.
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| http://dx.doi.org/10.3109/09513590.2013.801438 | DOI Listing |
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