AI Article Synopsis
- Resistance to certain antibiotics in Clostridium difficile is mainly due to erm(B) genes, particularly noted in the context of Tn5398.
- This study focused on different genetic elements from Tn5398 and found that Tn6194, a conjugative transposon, was commonly present in C. difficile strains from a 2005 European surveillance study.
- The research identified a Tn6194-like element and a rare novel element, and demonstrated that acquiring these genetic elements, along with Tn5398, negatively impacted the in vitro fitness of C. difficile.
Article Abstract
In Clostridium difficile, resistance to the macrolide-lincosamide-streptogramin B group of antibiotics generally relies on erm(B) genes. In this study, we investigated elements with a genetic organization different from Tn5398, the mobilizable non-conjugative element identified in C. difficile strain 630. Our results suggested that the elements most frequently found in strains isolated during the European surveillance study in 2005 were related to Tn6194, the conjugative transposon recently detected in different C. difficile types, including PCR-ribotype 027. We characterized a Tn6194-like and a novel element rarely found in clinical isolates. A burden on the in vitro fitness of C. difficile was observed after the acquisition of these elements as well as of Tn5398.
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| http://dx.doi.org/10.1099/jmm.0.057117-0 | DOI Listing |
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