Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/chem.201301347 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Oxi-Redox Selective Breast Cancer Treatment: An In Vitro Study of Theranostic In-Based Oxide Nanoparticles for Controlled Generation or Prevention of Oxidative Stress.
ACS Appl Mater Interfaces
January 2021
Institute for Superconducting and Electronic Materials, Australian Institute for Innovative Materials, University of Wollongong, 2500 North Wollongong, New South Wales, Australia.
In this article, we demonstrate that specifically engineered oxide nanoparticles (NPs) have the potential to act as theranostic materials that are able to generate or prevent oxidative stress through their oxi-redox activity in various types of malignant and nonmalignant cells. The oxi-redox activity is related to the type and presence of surface defects, which is modified with appropriate synthesis conditions. In the present work, we used MDA-MB-231 and MCF-7 human breast cancer cells and nonmalignant MCF-10A human breast cells to demonstrate how controlled oxidative stress mediated by specifically nanoengineered indium tin oxide (ITO) NPs can selectively induce cell death in the cancer cells while reducing the oxidative stress in the normal cells and supporting their proliferation.
View Article and Find Full Text PDFAntitumor Activity and Mechanistic Characterization of APE1/Ref-1 Inhibitors in Bladder Cancer.
Mol Cancer Ther
November 2019
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana.
Bladder cancer is the ninth most common cause of cancer-related deaths worldwide. Although cisplatin is used routinely in treating bladder cancer, refractory disease remains lethal for many patients. The recent addition of immunotherapy has improved patient outcomes; however, a large cohort of patients does not respond to these treatments.
View Article and Find Full Text PDFElectrochemically Driven Supramolecular Interaction of Quinones and Ferrocifens: An Example of Redox Activation of Bioactive Compounds.
Curr Top Med Chem
December 2014
Instituto de Química e Biotecnologia, UFAL, Maceió, Al, 57072-970, Brazil.
This review discusses the state of the art, challenges and perspectives in recent applications of electrochemistry in the life sciences. It deals mainly with the elucidation of molecular mechanisms of drug action, drug design and development, involving electron transfer, pharmaco-electrochemistry (the combination of electrochemical and pharmacological assays), and electrochemical studies of membrane models and drug delivery. It aims to shed light on the question: does electrochemistry really contribute to this area? It includes a general introduction for the use of electrochemistry in the life sciences, with a focus on how electrochemistry can uniquely provide both kinetic and thermodynamic information.
View Article and Find Full Text PDFElectrochemically driven supramolecular interaction of quinones and ferrocifens: an example of redox activation of bioactive compounds.
Curr Top Med Chem
February 2016
Instituto de Quimica e Biotecnologia, UFAL, Maceio, Al, 57072-970, Brazil.
This review discusses the state of the art, challenges and perspectives in recent applications of electrochemistry in the life sciences. It deals mainly with the elucidation of molecular mechanisms of drug action, drug design and development, involving electron transfer, pharmaco-electrochemistry (the combination of electrochemical and pharmacological assays), and electrochemical studies of membrane models and drug delivery. It aims to shed light on the question: does electrochemistry really contribute to this area? It includes a general introduction for the use of electrochemistry in the life sciences, with a focus on how electrochemistry can uniquely provide both kinetic and thermodynamic information.
View Article and Find Full Text PDFRedox-selective generation of aldehydes and H2 from alcohols under visible light.
Chemistry
July 2013
Research Center for Materials Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!