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Association between type 2 diabetes mellitus and Klebsiella pneumoniae colonization: construction of nomogram model.
Am J Transl Res
December 2024
Department of Infectious Diseases, Shanghai Fifth People's Hospital Shanghai 200240, China.
Objective: To investigate the association between the basic and clinical characteristics of patients with type 2 diabetes mellitus (T2DM) and their susceptibility to Klebsiella pneumoniae colonization (KPC). Additionally, a clinical prediction model was developed to identify high-risk patients for KPC.
Methods: Data from 486 T2DM patients who visited Shanghai Fifth People's Hospital from December 2020 to December 2022 were retrospectively collected.
Targeted sequencing of bacteria using CRISPR-Cas9 enrichment and Oxford Nanopore Technologies.
mSystems
January 2025
Department of Infectious Diseases, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.
Unlabelled: Sequencing DNA directly from patient samples enables faster pathogen characterization compared to traditional culture-based approaches, but often yields insufficient sequence data for effective downstream analysis. CRISPR-Cas9 enrichment is designed to improve the yield of low abundance sequences but has not been thoroughly explored with Oxford Nanopore Technologies (ONT) for use in clinical bacterial epidemiology. We designed CRISPR-Cas9 guide RNAs to enrich the human pathogen , by targeting multi-locus sequence type (MLST) and transfer RNA (tRNA) genes, as well as common antimicrobial resistance (AMR) genes and the resistance-associated integron gene .
View Article and Find Full Text PDFAntibiotic Stewardship Based on Colonization with Multi-Drug-Resistant Bacteria in Liver Transplantation: A Narrative Review.
Microorganisms
December 2024
Department of Diagnostic, Paediatric, Clinical and Surgical Science, University of Pavia, 27100 Pavia, Italy.
In solid organs post-transplant, bacterial infections can complicate the course of recovery with devastating consequences, such as graft loss and death. We provide an expert review on early post-liver transplant bacterial infections, with a focus on infections with multi-drug-resistant organism (MDRO) etiologies. Best practice recommendations are derived from a combination of available evidence and expert consensus.
View Article and Find Full Text PDFGastrointestinal (GI) colonization by methicillin-resistant (MRSA) is associated with a high risk of transmission and invasive disease in vulnerable populations. The immune and microbial factors that permit GI colonization remain unknown. Male sex is correlated with enhanced nasal carriage, skin and soft tissue infections, and bacterial sepsis.
View Article and Find Full Text PDFEpidemiological and bacteriological trends from 2013 to 2023 of carbapenemase-producing enterobacterales (CPE) in a French university hospital: A permanent risk of outbreak.
Infect Dis Now
December 2024
Service d'Hygiène Hospitalière, Centre Hospitalier Universitaire de Nantes, Nantes, R-44093, France; Nantes Université, UR 1155 IICiMED Lab, Institut de Recherche en Santé IRS2, Nantes, FR-44035, France. Electronic address:
Aim: The aim of this study was to describe the epidemiology and bacteriological trends of carbapenemase-producing Enterobacteriaceae (CPE) at Nantes University Hospital from 2013 to 2023.
Methods: Potential CPE carriers were prospectively detected, and their contacts were systematically screened for CPE digestive colonization. A retrospective study was conducted from 2013 to 2023 (on patient characteristics) and from 2016 to 2023 (on CPE characteristics).
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