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Point-of-care testing and the control of infectious diseases. | LitMetric

Point-of-care testing and the control of infectious diseases.

Biomark Med

Center for Biomedical Research, Burnet Institute, 85 Commercial Road, Melbourne, Victoria 3004, Australia.

Published: June 2013

AI Article Synopsis

  • Point-of-care tests (POCTs) help connect lab diagnostics to healthcare providers, crucial for quick diagnoses of diseases like HIV/AIDS and TB.
  • The effectiveness of POCTs relies on integrating them into comprehensive healthcare programs for better patient management.
  • Future development should focus on affordable POCTs that can utilize established lab biomarkers, particularly for molecular tests related to drug resistance in TB and viral loads in HIV and hepatitis.

Article Abstract

Point-of-care tests (POCTs) play an important role in bridging the gap between centralized laboratory diagnostics and peripheral healthcare service providers. Particularly in infectious diseases such as HIV/AIDS and TB where early detection is imperative to improve disease outcome, uptake of an accurate test that is simple, rapid and robust can significantly alter the epidemiology and control of the disease. However, a good POCT can only serve its full potential when adopted in a comprehensive programmatic context linking patients to on-site case management. Immunochromatographic lateral flow devices for detection of antibody or antigen currently dominate available POCTs, and development of such devices has relied on the discovery and optimization of definitive biomarkers suitable for such platforms. In the future, however, there will be an increasing need to develop cost-effective POCTs that address biomarkers that are well established in laboratory settings but are not currently amenable to point-of-care, such as molecular tests for drug resistance in TB and viral load in HIV and viral hepatitis.

Download full-text PDF

Source
http://dx.doi.org/10.2217/bmm.13.57DOI Listing

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