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Protein absorption in the zebrafish gut is regulated by interactions between lysosome rich enterocytes and the microbiome.
Elife
March 2025
Department of Cell Biology, Duke University, Durham, Durham, United States.
Dietary protein absorption in neonatal mammals and fishes relies on the function of a specialized and conserved population of highly absorptive lysosome-rich enterocytes (LREs). The gut microbiome has been shown to enhance absorption of nutrients, such as lipids, by intestinal epithelial cells. However, whether protein absorption is also affected by the gut microbiome is poorly understood.
View Article and Find Full Text PDFArtificial Lipidation of Antifungal Proteins and Antifungal Behavior: A Case Study with Cholesterylation.
Chembiochem
March 2025
Kyushu University: Kyushu Daigaku, Applied Chemistry, 744 Motooka, Nishi-ku, 819-0395, Fukuoka, JAPAN.
Lipid-based formulation of antifungal small drugs is used to mitigate drug toxicity while retaining effective antifungal activity. Our previous work demonstrated a method to enhance the antifungal properties of a chitin-binding domain (LysM) and catalytic domain (CatD) of antifungal chitinase by microbial transglutaminase (MTG)-mediated palmitoylation. Herein, we studied the effect of artificial cholesterylation of LysM and CatD, both of which were site-specifically modified using an MTG-catalyzed crosslinking.
View Article and Find Full Text PDFAn endoplasmic reticulum-associated structure sequesters misassembled FG-Nups to help maintain NPC function.
J Cell Sci
March 2025
Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Misassembly of nucleoporins (Nups), central components of the nuclear pore complex (NPC), leads to Nup mislocalization outside of the nuclear envelope. Here we elucidate the fate of mislocalized Nups. To impair Nup assembly, we depleted the structural component Nup98 and found that nucleo-cytoplasmic transport by NPC remains largely intact.
View Article and Find Full Text PDFNLRP3 inflammasome in cardiovascular diseases: an update.
Front Immunol
March 2025
People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Cardiovascular disease (CVD) continues to be the leading cause of mortality worldwide. The nucleotide oligomerization domain-, leucine-rich repeat-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is involved in numerous types of CVD. As part of innate immunity, the NLRP3 inflammasome plays a vital role, requiring priming and activation signals to trigger inflammation.
View Article and Find Full Text PDFNatural products for the treatment of ulcerative colitis: focus on the JAK/STAT pathway.
Front Immunol
March 2025
Department of Gastroenterology, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.
Ulcerative colitis (UC) is an autoimmune disease with an incompletely understood pathogenesis. The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway plays a key role in immune response and inflammation. More and more studies demonstrated that JAK/STAT signaling pathway is associated with the pathogenesis of UC.
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