CD137 is ectopically expressed on Hodgkin and Reed-Sternberg (HRS) cells, causing the removal of the immunostimulatory CD137 ligand from HRS cells as well as from surrounding antigen presenting cells. This inhibits T-cell co-stimulation and supports the immune evasion of Hodgkin's lymphoma.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654577 | PMC |
| http://dx.doi.org/10.4161/onci.23441 | DOI Listing |
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