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T cell aging: a review of the transcriptional changes determined from genome-wide analysis. | LitMetric

T cell aging: a review of the transcriptional changes determined from genome-wide analysis.

Front Immunol

Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health Baltimore, MD, USA.

Published: June 2013

AI Article Synopsis

Article Abstract

Age carries a detrimental impact on T cell function. In the past decade, analyses of the genome-scale transcriptional changes of T cells during aging have yielded a large amount of data and provided a global view of gene expression changes in T cells from aged hosts as well as subsets of T cells accumulated with age. Here, we aim to review the changes of gene expression in thymocytes and peripheral mature T cells, as well as the subsets of T cells accumulated with age, and discuss the gene networks and signaling pathways that are altered with aging in T cells. We also discuss future direction for furthering the understanding of the molecular basis of gene expression alterations in aged T cells, which could potentially provide opportunities for gene-based clinical interventions.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657702PMC
http://dx.doi.org/10.3389/fimmu.2013.00121DOI Listing

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