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Aquatic high iron induces hepatic ferroptosis in zebrafish (Danio rerio) via interleukin-22 signaling pathway.
Environ Pollut
January 2025
Key Laboratory of Aquaculture Nutrition and Feed, Ministry of Agriculture & Key Laboratory of Mariculture, Ministry of Education, College of Fisheries, Ocean University of China, Qingdao, China; Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao Marine Science and Technology Center, Qingdao, Shandong, 266237, China. Electronic address:
Iron is one of the indispensable trace elements in living organisms. However, excessive iron deposition in organisms is prone to induce dysfunction of the liver and other vital organs. The present study aimed to investigate the mechanism how aquatic high iron affects iron transport and induces hepatic injury in zebrafish.
View Article and Find Full Text PDFInterleukin-22 promotes endometrial carcinoma cell proliferation and cycle progression via ERK1/2 and p38 activation.
Mol Cell Biochem
December 2024
Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, 300052, China.
Endometrial carcinoma (EC) is one of the most common gynecological malignant tumors, but its underlying pathogenic mechanisms are largely obscure. Interleukin-22 (IL-22), one cytokine in the tumor immune microenvironment, was reported to be associated with carcinoma progression. Here, we aimed to investigate the regulation of IL-22 in endometrial carcinoma.
View Article and Find Full Text PDFCorrelation between serum IL-22 and IL-27 levels and vasculopathy in diabetic nephropathy patients.
Am J Transl Res
October 2024
Department of Laboratory, Shanxi University of Traditional Chinese Medicine Affiliated Hospital Taiyuan 030024, Shanxi, China.
Objective: To explore the correlation between serum interleukin-22 (IL-22) and interleukin-27 (IL-27) levels and vasculopathy in patients with diabetic nephropathy (DN).
Methods: A total of 104 DN patients treated at the Shanxi University of Traditional Chinese Medicine Affiliated Hospital were selected as the observation group, with another 104 healthy individuals, serving as the control group in this retrospective study. The baseline data and the serum levels of IL-22 and IL-27 were compared between the two groups.
Nanotherapeutics-mediated restoration of pancreatic homeostasis and intestinal barrier for the treatment of severe acute pancreatitis.
J Control Release
January 2025
Department of Gastroenterology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China. Electronic address:
Article Synopsis
- - Severe acute pancreatitis (SAP) is a serious inflammatory condition of the pancreas with limited treatment options, prompting the development of a new nanotherapeutic called pHA@IBNCs to alleviate inflammation and restore intestinal health.
- - The pHA@IBNCs are formed by combining an antioxidant (EGCG), an anti-inflammatory cytokine (IL-22), and a framework protein (bovine serum albumin), then coated with a modified hyaluronic acid to target damaged cells in the pancreas and intestines.
- - When administered, the pHA@IBNCs effectively accumulate at inflammation sites, releasing their therapeutic agents in response to the high levels of reactive oxygen species (ROS) present, which helps reduce inflammation and
Progranulin protects against infection by enhancing IL-22 production.
Gut Microbes
September 2024
Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Article Synopsis
- Enhanced mortality and relapse rates of Clostridioides difficile infection (CDI) highlight the urgent need for improved therapies, as current antibiotic options are insufficient.
- Researchers found that progranulin (PGRN) plays a key role in immune response during CDI, with PGRN-deficient mice showing higher mortality and more intestinal damage despite similar infection levels.
- PGRN protects against CDI by promoting the production of IL-22 from CD4 T helper cells, suggesting that targeting the host's immune response could offer a new strategy for treating severe CDI cases.
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