AI Article Synopsis
- Researchers isolated and studied a new insect nidovirus from the mosquito species Culex tritaeniorhynchus in Vietnam, naming it Dak Nong virus (DKNV).
- DKNV is part of the newly identified family Mesoniviridae and shares similarities with other recently found viruses, suggesting they should be grouped as a single species called Alphamesonivirus 1.
- The virus can grow in mosquito cells but not in vertebrate cells, and its structural proteins showed specific features that enhance our understanding of the Mesoniviridae family.
Article Abstract
In this study, we isolated and characterized an insect nidovirus from the mosquito Culex tritaeniorhynchus Giles (Diptera: Culicidae) in Vietnam, as an additional member of the new family Mesoniviridae in the order Nidovirales. The virus, designated "Dak Nong virus (DKNV)," shared many characteristics with Cavally virus and Nam Dinh virus, which have also been discovered recently in mosquitoes, and these viruses should be considered members of a single virus species, Alphamesonivirus 1. DKNV grew in cultured mosquito cells but could not replicate in the cultured vertebrate cells tested. N-terminal sequencing of the DKNV structural proteins revealed two posttranslational cleavage sites in the spike glycoprotein precursor. DKNV is assumed to be a new member of the species Alphamesonivirus 1, and the current study provides further understanding of viruses belonging to the new family Mesoniviridae.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087109 | PMC |
| http://dx.doi.org/10.1007/s00705-013-1741-4 | DOI Listing |
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