Nowadays, bipedal walking is undergoing extensive study. Several methods can be used in physiotherapeutic research for identifying defects in bipedal walking as a result of pathology of the musculoskeletal or nervous system. Our work focuses on studying asymmetry of walking based on synchronized bilateral knee-knee cyclograms. Participants presenting with peroneal nerve palsy and foot drop were included in the study. The bilateral cyclograms, also called angle-angle diagrams, were created to quantify gait asymmetry before and immediately after application of a brace. In order to quantify the asymmetry of human walking, we have described and tested the application of the method based on the inclination angle of the synchronized bilateral cyclograms. The symmetry index (SI) was used as a comparative method to evaluate the symmetry of bipedal walking. The method based on the orientation of the cyclograms can be used as an additional method for determining the gait asymmetry. The new technique has never been applied before to study the gait asymmetry in patients with peroneal nerve palsy or patients with leg brace.
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Gene Ther
January 2025
School of Pharmacy, East China University of Science and Technology, Shanghai, China.
Osteoarthritis (OA), a prevalent joint disorder, can lead to disability, with no effective treatment available. Interleukin-1 (IL-1) plays a crucial role in the progression of OA, and its receptor antagonist (IL-1Ra), a natural IL-1 inhibitor, represents a promising therapeutic target by obstructing the IL-1 signaling pathway. This study delivered IL-1Ra via adeno-associated virus (AAV), a gene therapy vector enabling long-term protein expression, to treat knee osteoarthritis (KOA) in animal models.
View Article and Find Full Text PDFMed Sci Monit
January 2025
Department of Physical Education, Pusan National University, Busan, South Korea.
BACKGROUND The VICON Toolkit enables three-dimensional (3D) motion capture for gait analysis. Statistical parametric mapping (SPM) is a voxel-based neuroimaging approach used to identify region-specific effects. This study aimed to apply SPM to analyze the joint angles of the hip, knee, and ankle during gait in 20 post-stroke patients using the VICON motion capture system.
View Article and Find Full Text PDFNeurorehabil Neural Repair
January 2025
Department of Human Movement Science, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, The Netherlands.
Background: How gait changes during the early stages of stoke rehabilitation, and which patient characteristics are associated with these changes is still largely unknown.
Objective: he first objective was to describe the changes in gait during stroke rehabilitation. Secondly, we determined how various patient characteristics were associated with the rate of change of gait over time.
Sensors (Basel)
December 2024
Department of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne NE1 8ST, UK.
The analysis of running gait has conventionally taken place within an expensive and restricted laboratory space, with wearable technology offering a practical, cost-effective, and unobtrusive way to examine running gait in more natural environments. This pilot study presents a wearable inertial measurement unit (IMU) setup for the continuous analysis of running gait during an outdoor parkrun (i.e.
View Article and Find Full Text PDFCureus
December 2024
Department of Rehabilitation, Musashigaoka Hospital, Kumamoto, JPN.
Gait asymmetry in post-stroke patients is an important gait characteristic that is associated with their balance control, inefficiency, and risks of musculoskeletal injury to the non-paretic lower limb and falling. Unfortunately, most stroke patients retain an asymmetrical gait pattern, even though their gait independence and gait speed improve. We describe the clinical course of a subacute stroke patient who achieved a symmetrical gait at discharge after undergoing both gait training with orthoses and robot-assisted gait training from the early intervention phase.
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