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Protection against avian necrotic enteritis after immunisation with NetB genetic or formaldehyde toxoids. | LitMetric

AI Article Synopsis

  • NetB is a toxin produced by Clostridium perfringens that contributes to necrotic enteritis in poultry, especially after the banning of antimicrobial growth promoters.
  • Research aimed to test if immunizing birds with a NetB toxoid could protect them from this disease.
  • Immunization with either a formaldehyde or genetic variant of the NetB toxoid triggered antibody responses and offered partial protection against necrotic enteritis.

Article Abstract

NetB (necrotic enteritis toxin B) is a recently identified β-pore-forming toxin produced by Clostridium perfringens. This toxin has been shown to play a major role in avian necrotic enteritis. In recent years, a dramatic increase in necrotic enteritis has been observed, especially in countries where the use of antimicrobial growth promoters in animal feedstuffs has been banned. The aim of this work was to determine whether immunisation with a NetB toxoid would provide protection against necrotic enteritis. The immunisation of poultry with a formaldehyde NetB toxoid or with a NetB genetic toxoid (W262A) resulted in the induction of antibody responses against NetB and provided partial protection against disease.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763374PMC
http://dx.doi.org/10.1016/j.vaccine.2013.05.063DOI Listing

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