Reporting in Nature, Sanders et al. (2013) implicate filopodial projections in Sonic hedgehog (Shh) patterning of the limb. Actin-based filopodia transport Shh from producing cells, while filopodia of responding cells bear Cdon and Boc: coreceptors in the Shh pathway. These findings suggest a new mechanism of ligand movement and transmission.
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