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Assessment and Correlation of TP53 With Histological Parameters of Oral Squamous Cell Carcinoma.
Cureus
December 2024
Department of Pathology, Government Medical College Satna, Satna, IND.
Background Oral squamous cell carcinoma is a common problem among tobacco chewers and related products in developing countries like India. Histopathological examination evaluates and confirms the diagnosis of oral SCC. Clinical examination and molecular profiling by histopathological examination (HPE) are important prognostic tools used in clinical practice.
View Article and Find Full Text PDFUnveiling Clinically Significant Anti-Lewis Antibodies: A Case Report.
Cureus
December 2024
Department of Pathology and Medical Laboratory, Faculty of Medicine, Universiti Sultan Zainal Abidin, Kuala Terengganu, MYS.
Lewis antibodies, such as anti-Le and anti-Le, are commonly encountered in routine immunohematology. They are typically IgM in nature and are generally considered clinically insignificant, as they rarely cause hemolytic transfusion reactions (HTRs) or hemolytic disease of the fetus and newborn (HDFN). However, rare cases have been reported where anti-Lewis antibodies caused mild transfusion reactions.
View Article and Find Full Text PDFA multi-patch-based deep learning model with VGG19 for breast cancer classifications in the pathology images.
Digit Health
January 2025
School of IT and Engineering, Melbourne Institute of Technology, Melbourne, Australia.
Purpose: Breast cancer encompasses various subtypes with distinct prognoses, necessitating accurate stratification methods. Current techniques rely on quantifying gene expression in limited subsets. Given the complexity of breast tissues, effective detection and classification of breast cancer is crucial in medical imaging.
View Article and Find Full Text PDFRecommendations for reporting and evaluating proton therapy beyond dose and constant relative biological effectiveness.
Phys Imaging Radiat Oncol
January 2025
Center for Proton Therapy, Paul Scherrer Institute, Villigen PSI, Switzerland.
Background And Purpose: In proton therapy, a relative biological effectiveness (RBE) of 1.1 is used to convert proton dose into an equivalent photon dose. However, RBE varies with tissue type, fraction dose, and beam quality parameters beyond dose such as linear energy transfer (LET) raising concerns about increased local effectiveness and potential toxicity.
View Article and Find Full Text PDFDetection of cervical precancerous lesions and cancer by small-scale RT-qPCR analysis of oppositely deregulated mRNAs pairs in cytological smears.
Front Oncol
January 2025
AO Vector-Best, Novosibirsk, Russia.
Background: Cervical screening, aimed at detecting precancerous lesions and preventing cancer, is based on cytology and HPV testing. Both methods have limitations, the main ones being the variable diagnostic sensitivity of cytology and the moderate specificity of HPV testing. Various molecular biomarkers are proposed in recent years to improve cervical cancer management, including a number of mRNAs encoded by human genes involved in carcinogenesis.
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