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Human sperm proteome reveals the effect of environmental borne seminal polyaromatic hydrocarbons exposome in etiology of idiopathic male factor infertility.
Front Cell Dev Biol
May 2023
Redox Biology & Proteomics Laboratory, Department of Zoology, Ravenshaw University, Cuttack, India.
Polyaromatic hydrocarbons (PAHs) are considered as redox active environmental toxicants inducing oxidative stress (OS) mediated injury to cells. Oxidative predominance is reported in 30%-80% of idiopathic male infertility (IMI) patients. Hence, this work aims to unravel correlation, if any, between seminal PAH exposome and sperm function in IMI patients through a proteomic approach.
View Article and Find Full Text PDFImage-based cell classification has become a common tool to identify phenotypic changes in cell populations. However, this methodology is limited to organisms possessing well-characterized species-specific reagents (, antibodies) that allow cell identification, clustering, and convolutional neural network (CNN) training. In the absence of such reagents, the power of image-based classification has remained mostly off-limits to many research organisms.
View Article and Find Full Text PDFOff-label, off-limits? Parental awareness and attitudes towards off-label use in paediatrics.
Eur J Pediatr
December 2009
Department for Medical Ethics and History of Medicine, University of Göttingen, Humboldtallee 36, 37073 Göttingen, Germany.
Off-label drug use in paediatrics is associated with an increased risk of adverse drug reactions. Any risk-benefit analysis has to be based on value judgments that should include parents' views. However, nothing is known so far about the parents' perspective on this critical issue.
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