The chloro-phenyl group of the title compound, C18H12ClNO4, is disordered over two orientations with occupancies of 0.331 (8) and 0.669 (8). An intra-molecular hydrogen bond is formed between a hy-droxy group and the acyclic carbonyl group. In the crystal, molecules are linked into chains along [110] by O-H⋯O and C-H⋯O hydrogen bonds, forming a ladder motif.
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http://dx.doi.org/10.1107/S1600536813009689 | DOI Listing |
Acta Crystallogr E Crystallogr Commun
January 2025
University of Lodz Faculty of Chemistry Pomorska 163/165 90-236 Łódź Poland.
The crystal structure of luliconazole {LCZ; CHClNS; systematic name: ()-[(4)-4-(2,4-di-chloro-phen-yl)-1,3-di-thio-lan-2-yl-idene](1-imidazol-1-yl)aceto-nitrile} is reported. In the mol-ecule of the title compound, the di-thiol-ane ring adopts an envelope conformation, while the di-chloro-phenyl ring exhibits disorder. In the crystal packing of luliconazole, only two inter-molecular C-H⋯N hydrogen bonds are observed.
View Article and Find Full Text PDFActa Crystallogr E Crystallogr Commun
October 2024
In the title mol-ecule, CHClNO, the 2-chloro-phenyl group is disordered to a small extent [occupancies 0.875 (2)/0.125 (2)].
View Article and Find Full Text PDFJ Mol Med (Berl)
December 2024
Laboratorio de Oncología y Transducción de Señales, Instituto de Química y Fisicoquímica Biológicas (IQUIFIB), Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, CONICET, Junin 956, C1113AAD, Buenos Aires, Argentina.
Metabolites
September 2024
Section of Legal Medicine, Department of Biomedical Sciences and Public Health, Marche Polytechnic University, 60126 Ancona, Italy.
Background: The abuse of psychoactive substances presents challenges in clinical and forensic toxicology. The emergence of novel and potent drugs that pose significant health risks, in particular towards frequent abusers and users unaware of the ingredients, further complicates the situation. Designer benzodiazepines have become a fast-growing subgroup of these new psychoactive substances (NPSs), and their overdose may potentially turn fatal, especially when combined with other central nervous system depressants.
View Article and Find Full Text PDFToxicol Appl Pharmacol
October 2024
Federal University of Santa Maria, Center for Natural and Exact Sciences, Department of Biochemistry and Molecular Biology, Postgraduate Program in Biological Sciences: Toxicological Biochemistry, Camobi, Zip code 97105-900 Santa Maria, RS, Brazil. Electronic address:
Antiretrovirals have improved considerably since the introduction of 3'-azido-3'-deoxythymidine (zidovudine or AZT), a molecule with also anticancer effects. Subsequently, a variety of other nucleosides have been synthesized. However, these medications are often associated with serious adverse events and the onset or exacerbation of degenerative processes, diseases, and syndromes, affecting mainly the mitochondria.
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