Unlabelled: Recently introduced high-efficiency SPECT cameras have demonstrated the ability to reduce radiation exposure to patients undergoing myocardial perfusion imaging studies, especially when combined with stress-only imaging protocols. To date there have been no relevant studies examining the reduced occupational radiation exposure to medical staff. We sought to determine whether changes in stress myocardial perfusion imaging protocols and camera technology can reduce the occupational radiation exposure to the staff of a nuclear cardiology laboratory.
Methods: Monthly radiation dosimeter readings from 4 nuclear technologists, 4 nurses, and 2 administrative employees were analyzed from two 12-mo periods: October 2007-September 2008 (period 1), before the use of high-efficiency SPECT, and October 2010-September 2011 (period 2), after high-efficiency SPECT was introduced. The average monthly dose equivalent in millirems (1 mrem = 0.01 mSv) was recorded from personal dosimeters worn on laboratory coats. The total activity of (99m)Tc used per month, mean (99m)Tc administered activity per patient, average number of patients per month, patient time spent in the laboratory, and proportion of stress-only studies were determined.
Results: There were 3,539 patients in period 1 and 3,898 in period 2. An approximately 40% reduction in the dose equivalent across all staff members occurred during this time (-16.9 and -16.2 mrem for nuclear technologists and nurses, respectively; P < 0.0001). During period 2, the total activity of (99m)Tc used per month decreased (10,746 vs. 7,174 mCi [1 mCi = 37 MBq], P < 0.0001), as did the mean (99m)Tc administered activity per patient (36.5 vs. 23.8 mCi, P < 0.0001). The percentage of patients having stress-only imaging increased (35% vs. 56%, P < 0.0001), and the total patient time spent in the laboratory decreased. Radiation dose equivalent levels were reduced in period 2 to 1%-7% of the allowed annual occupational dose equivalent. The combination of the use of high-efficiency SPECT technology and stress-only protocols resulted in a 34.7% reduction in mean total (99m)Tc administered activity between time periods, with camera technology being responsible for 39.2% of the reduction and stress-only protocols for 60.8%.
Conclusion: A combination of high-efficiency SPECT technology and selective use of stress-only protocols significantly reduces the occupational radiation dose equivalent to the staff of a nuclear cardiology laboratory.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.2967/jnumed.112.112680 | DOI Listing |
ACS Omega
October 2024
Department of Biophysics and Radiation Biology, Semmelweis University, Budapest 1094, Hungary.
Bacterial outer membrane vesicles (OMVs) are emerging as important players in the host-microbiome interaction, while also proving to be a promising platform for vaccine development and targeted drug delivery. The available methods for measuring their biodistribution, however, are limited. We aimed to establish a high-efficiency radiolabeling method for the treatment of OMVs.
View Article and Find Full Text PDFJ Control Release
September 2024
Department of Radiology, Changhai Hospital, Naval Medical University, Shanghai, China. Electronic address:
Curcumin potentiates the stabilization of atherosclerotic plaques by polarizing macrophages, but its non-specific targeting hinders its clinical application. We aim to harness multifunctional lipid nanoparticles (MLNPs) to facilitate the imaging and targeted delivery of curcumin specifically to inflammatory macrophages, counteracting vulnerable plaques and mitigating the risk of ischemic events. Cholesteryl-9-carboxynonanoate-(I‑iron oxide nanoparticle/Curcumin)-lipid-coated nanoparticles [9-CCN-(I-ION/Cur)-LNPs], namely MLNPs, are designed to carry hybrid imaging agents.
View Article and Find Full Text PDFEJNMMI Radiopharm Chem
May 2024
Nuclear Medicine Unit, Department of Oncohaematology, Fondazione PTV Policlinico Tor Vergata University Hospital, Rome, Italy.
Background: In recent years, fibroblast activating protein (FAP), a biomarker overexpressed by cancer-associated fibroblasts, has emerged as one of the most promising biomarkers in oncology. Similarly, FAP overexpression has been detected in various fibroblast-mediated inflammatory conditions such as liver cirrhosis and idiopathic pulmonary fibrosis. Along this trajectory, FAP-targeted positron emission tomography (PET), utilizing FAP inhibitors (FAPi) labeled with positron emitters, has gained traction as a powerful imaging approach in both cancer and inflammation.
View Article and Find Full Text PDFJ Nucl Cardiol
December 2023
Cardiology Division, Department of Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 679-N, Rochester, NY, 14642-8679, USA.
Circ Cardiovasc Imaging
June 2022
Department of Medicine (Division of Artificial Intelligence), Imaging, and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles (B.K.T., Y.O., L.-H.H., H.G., E.E., J.X.L., D.D., D.S.B., P.J.S.).
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!