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Effects of gas exchange on acid-base balance. | LitMetric

Effects of gas exchange on acid-base balance.

Compr Physiol

Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.

Published: July 2012

AI Article Synopsis

  • The paper explores how ventilation and acid-base balance interact under different conditions like rest, exercise, and pregnancy, as well as various health issues.
  • It introduces a physicochemical method for assessing acid-base status and shows how this approach helps to identify sources of acid-base disorders through examples from existing research.
  • The study highlights the complex relationship between ventilation and acid-base balance, emphasizing the need for more comprehensive research to better understand these interactions, particularly during exercise and in various medical conditions.

Article Abstract

This paper describes the interactions between ventilation and acid-base balance under a variety of conditions including rest, exercise, altitude, pregnancy, and various muscle, respiratory, cardiac, and renal pathologies. We introduce the physicochemical approach to assessing acid-base status and demonstrate how this approach can be used to quantify the origins of acid-base disorders using examples from the literature. The relationships between chemoreceptor and metaboreceptor control of ventilation and acid-base balance summarized here for adults, youth, and in various pathological conditions. There is a dynamic interplay between disturbances in acid-base balance, that is, exercise, that affect ventilation as well as imposed or pathological disturbances of ventilation that affect acid-base balance. Interactions between ventilation and acid-base balance are highlighted for moderate- to high-intensity exercise, altitude, induced acidosis and alkalosis, pregnancy, obesity, and some pathological conditions. In many situations, complete acid-base data are lacking, indicating a need for further research aimed at elucidating mechanistic bases for relationships between alterations in acid-base state and the ventilatory responses.

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Source
http://dx.doi.org/10.1002/cphy.c100055DOI Listing

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