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Purification, crystallization and preliminary X-ray crystallographic studies of the Mycobacterium tuberculosis DNA gyrase ATPase domain. | LitMetric

Purification, crystallization and preliminary X-ray crystallographic studies of the Mycobacterium tuberculosis DNA gyrase ATPase domain.

Acta Crystallogr Sect F Struct Biol Cryst Commun

Unité de Microbiologie Structurale, Institut Pasteur, CNRS UMR 3528, 25 rue du Dr Roux, 75015 Paris, France.

Published: June 2013

AI Article Synopsis

Article Abstract

Mycobacterium tuberculosis DNA gyrase, a nanomachine involved in the regulation of DNA topology, is the only type II topoisomerase present in this organism and hence is the sole target of fluoroquinolones in the treatment of tuberculosis. The ATPase domain provides the energy required for catalysis by ATP hydrolysis. Two constructs corresponding to this 43 kDa domain, Mtb-GyrB47(C1) and Mtb-GyrB47(C2), have been overproduced, purified and crystallized. Diffraction data were collected from three crystal forms. The crystals belonged to space groups P1 and P21 and diffracted to resolutions of 2.9 and 3.3 Å, respectively.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668594PMC
http://dx.doi.org/10.1107/S1744309113012906DOI Listing

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