Aim: To determine the effect of plasma homocysteine (Hc) on the structure and function of the left ventricle (LV) in patients treated by programmed hemodialysis.
Subjects And Methods: 109 patients on programmed hemodialysis were examined. Blood Hc levels were determined and echocardiography was performed in all the patients.
Results: In the patients on programmed hemodialysis, Hc concentrations were significantly higher than in apparently healthy individuals; there was a preponderance of mild (49.5%) and moderate (43.1%) hyperhomocysteinemia. LV hypertrophy was diagnosed in 90.8% of the patients. A positive relationship was found between the concentrations of Hc and the E/A ratio (r = 0.34; p = 0.05), isovolumetric relaxation time (IRT) (r = 0.32; p = 0.03), and LV mass (LVM) (r = 0.3; p = 0.05). Multivariate regression analysis indicated that the level of Hc had an independent impact on the E peak (R2 = 0.3; p = 0.05), LV relative wall thickness (RWT) (R2 = 0.38; p = 0.03), and LV IRT (R2 = 0.3; p = 0.06).
Conclusion: Elevated plasma Hc levels were found to be related to LVM, LV RWT, LV IRT, E peak, and E/A ratio, suggesting that Hc had an unfavorable effect on the LV structure and function in patients on hemodialysis.
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