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Alcohol use disorder (AUD) is known to have a significant genetic component, yet there remains a substantial gap between its heritability and findings from genome-wide association studies. One potential factor contributing to this gap may be genetic interactions, or epistasis, a largely unexplored aspect in the context of AUD. The aim of this study was to investigate the role of epistasis in AUD susceptibility and severity among American Indians, a population that exhibits the highest rates of AUD among all ethnic groups in the U.
View Article and Find Full Text PDFGenetic interaction network of quantitative trait genes for heading date in rice.
J Genet Genomics
January 2025
Shanghai Key Laboratory of Plant Molecular Sciences, Shanghai Engineering Research Center of Plant Germplasm Resources, College of Life Sciences, Shanghai Normal University, Shanghai, 200234, China. Electronic address:
Several quantitative trait genes (QTGs) related to rice heading date, a key factor for crop development and yield, have been identified, along with complex interactions among genes. However, a comprehensive genetic interaction network for these QTGs has not yet been established. In this study, we use 18K-rice lines to identify QTGs and their epistatic interactions affecting rice heading date.
View Article and Find Full Text PDFThe Role of Pleiotropy and Epistasis on Evolvability and Robustness in a Two-Peak Fitness Landscape.
Biology (Basel)
December 2024
Department for MicroData Analytics, Dalarna University, 791 88 Falun, Sweden.
Understanding the balance between robustness and evolvability is crucial in evolutionary dynamics. This study aims to determine how varying mutation rates and valley depths affect this interplay during adaptation. Using a two-peak fitness landscape model requiring populations to cross a fitness valley to reach a higher peak, we investigate how mutation rates and valley depths influence both evolvability-the capacity to generate beneficial mutations-and mutational robustness, which stabilizes populations at the highest peak.
View Article and Find Full Text PDFError thresholds in the presence of epistatic interactions.
Phys Rev E
November 2024
Université Grenoble Alpes, CEA List, 38000 Grenoble, France.
Models for viral populations with high replication error rates (such as RNA viruses) rely on the quasispecies concept, in which mutational pressure beyond the so-called "error threshold" leads to a loss of essential genetic information and population collapse, an effect known as the "error catastrophe." We explain how crossing this threshold, as a result of increasing mutation rates, can be understood as a second-order phase transition, even in the presence of lethal mutations. In particular, we show that, in fitness landscapes with a single peak, this collapse is equivalent to a ferroparamagnetic transition, where the back-mutation rate plays the role of the external magnetic field.
View Article and Find Full Text PDFEvolutionary insights into the stereoselectivity of imine reductases based on ancestral sequence reconstruction.
Nat Commun
November 2024
State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing, East China University of Science and Technology, Shanghai, China.
The stereoselectivity of enzymes plays a central role in asymmetric biocatalytic reactions, but there remains a dearth of evolution-driven biochemistry studies investigating the evolutionary trajectory of this vital property. Imine reductases (IREDs) are one such enzyme that possesses excellent stereoselectivity, and stereocomplementary members are pervasive in the family. However, the regulatory mechanism behind stereocomplementarity remains cryptic.
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