AI Article Synopsis
- The study examined follicular populations in female F344/N rats to gain insight into ovarian aging, analyzing ovaries from rats aged 1 to 36 months.
- The research found that healthy follicle numbers significantly decreased during the first three months and continued to decline gradually afterwards, whereas corpora lutea (CL) remained stable until 18 months before decreasing.
- Interestingly, while the number of atretic follicles began to rise after 18 months, indicating aging effects, some healthy follicles and CL were still present in 36-month-old rats.
Article Abstract
Follicular populations were investigated in female F344/N rats to better understand the aging process of the rat ovary. Ovaries dissected at various ages (spanning 1-36 months old) were submitted for histological examination. The total number of primordial, growing (primary and secondary), tertiary, and atretic follicles as well as corpora lutea (CL) were counted in hematoxylin-eosin- and azocarmine-aniline-blue-stained ovarian sections. The number of healthy follicles including primordial, growing and tertiary follicles decreased rapidly between the first and third months and gradually thereafter. CL were found in 3-month-old rats, and their number remained unchanged until 18 months of age, at which point it decreased. The number of atretic follicles started to increase in rats older than 18 months, which corresponded to the cessation of estrous cyclicity. Several healthy follicles and CL were observed even in 36-month-old rats.
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| http://dx.doi.org/10.1016/j.repbio.2013.03.003 | DOI Listing |
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