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Sodium alginate/low methoxyl pectin composite hydrogel beads prepared via gas-shearing technology for enhancing the colon-targeted delivery of probiotics and modulating gut microbiota.
Int J Biol Macromol
January 2025
College of Food Science and Engineering, Shaanxi Engineering Research Centre of Dairy Products Quality, Safety and Health, Northwest A&F University, Yangling 712100, Shaanxi, China. Electronic address:
The probiotic encapsulation system has the potential to enhance the prebiotic effects of probiotics. However, challenges arise from the release behavior of this system in vivo and the large size of hydrogel beads. This study aims to address the issues related to the size of previous hydrogel beads and assess the colon-targeted delivery of probiotic polysaccharides composite hydrogel beads (PPHB).
View Article and Find Full Text PDFGiant inguinal hernia with mal-rotation in a resource-limited area: Case report.
Int J Surg Case Rep
January 2025
School of postgraduate, Amoud University, Somalia; Faculty of Science, Charles University, Czechia. Electronic address:
Introduction: Giant inguinoscrotal hernias (GIH), defined as hernias extending below the inner thigh midpoint in a standing position, are rare and often seen in resource-limited settings due to delayed medical care. These hernias pose surgical challenges, particularly in low- and middle-income countries (LMICs), where standardized management protocols are lacking, and risks such as cardiorespiratory compromise are significant.
Case Presentation: A 55-year-old male presented with a large, irreducible right inguinoscrotal hernia of 1.
Do people prefer AI-generated patient educational materials over traditional ones?
Patient Educ Couns
January 2025
University of Texas at Austin Dell Medical School, Austin, TX, United States.
Objective: This study aimed to assess people's preference between traditional and Artificial Intelligence (AI)-generated colon cancer staging Patient Education Materials (PEMs).
Methods: We assessed preference among patients and companions being seen for a non-cancer diagnosis at the UT Health Austin Colon and Rectal Surgery Clinic. Participants were blinded to the study concept of AI and generation method of PEMs (Traditional: National Cancer Institute and the American Cancer Society; AI-generated: ChatGPT and Google Bard).
Changyanning tablet alleviates Crohn's disease by inhibiting GPX4-mediated ferroptosis.
J Ethnopharmacol
January 2025
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100193, China. Electronic address:
Ethnopharmacological Relevance: Changyanning tablets (CYN) are a marketed traditional Chinese medicine composed of Diijincao (Euphorbia humifusa Willd.), Jinmaoercao (Hedyotis chrysotricha (Palib.) Merr.
View Article and Find Full Text PDFMechanism underlying the role of the circRNA OMA1/miR-654-3p/RAF1 axis in children with inflammatory bowel disease.
Cytotechnology
April 2025
Department of Child Health, Maternal and Child Health Hospital of Hubei Province, No. 745 Wuluo Road, Wuhan, 430070 China.
Unlabelled: Inflammatory bowel disease (IBD), a chronic gastrointestinal disorder, often emerges during childhood and poses significant challenges due to its adverse effects on growth, development, and psychosocial well-being. Circular RNAs (circRNAs) have been implicated in the pathogenesis of diverse diseases. However, the specific biological role and mechanisms of circRNA OMA1 in children with IBD remain largely unexplored.
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