Motivation: High-throughput phenotypic assays reveal information about the molecules that modulate biological processes, such as a disease phenotype and a signaling pathway. In these assays, the identification of hits along with their molecular targets is critical to understand the chemical activities modulating the biological system. Here, we present HitPick, a web server for identification of hits in high-throughput chemical screenings and prediction of their molecular targets. HitPick applies the B-score method for hit identification and a newly developed approach combining 1-nearest-neighbor (1NN) similarity searching and Laplacian-modified naïve Bayesian target models to predict targets of identified hits. The performance of the HitPick web server is presented and discussed.
Availability: The server can be accessed at http://mips.helmholtz-muenchen.de/proj/hitpick.
Contact: monica.campillos@helmholtz-muenchen.de.
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| http://dx.doi.org/10.1093/bioinformatics/btt303 | DOI Listing |
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View Article and Find Full Text PDFHitPick: a web server for hit identification and target prediction of chemical screenings.
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Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
Motivation: High-throughput phenotypic assays reveal information about the molecules that modulate biological processes, such as a disease phenotype and a signaling pathway. In these assays, the identification of hits along with their molecular targets is critical to understand the chemical activities modulating the biological system. Here, we present HitPick, a web server for identification of hits in high-throughput chemical screenings and prediction of their molecular targets.
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