AI Article Synopsis
- - This study introduces a method for creating unnatural (R)-α-amino acids by using a chiral reagent derived from α-(phenyl)ethylamine and mixing it with various (S)-α-amino acids.
- - The process yields significant chemical outputs and maintains controlled diastereoselectivity, ensuring the products are of high quality.
- - Additionally, the chiral reagent can be easily recovered and reused, retaining its enantiomeric purity and effectiveness without degradation.
Article Abstract
Here we report a general method for the preparation of unnatural (R)-α-amino acids via complexation of α-(phenyl)ethylamine derived chiral reagent (S)- with various (S)-α-amino acids. The reactions proceed with synthetically useful chemical yields and thermodynamically controlled diastereoselectivity. Chiral reagent (S)- can be conveniently recovered and reused without any loss of enantiomeric purity and reactivity.
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| http://dx.doi.org/10.1039/c3ob40541a | DOI Listing |
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