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Berberine Inhibits the Disruption of the Blood-Brain Barrier and Glial Cell Activation in a Rat Model of Acute Hepatic Encephalopathy.
Phytother Res
January 2025
Laboratory of Molecular NeuroTherapeutics, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Raebareli, Uttar Pradesh, India.
Background And Aim: Hepatic encephalopathy (HE) is a complex neurological disorder in individuals with liver diseases, necessitating effective neuroprotective interventions to alleviate its adverse outcomes. Berberine (BBR), a natural compound with well-established anti-fibrotic and neuroprotective properties, has not been extensively studied in the context of glial activation under hyperammonaemic conditions. This study evaluates the neuroprotective potential of BBR in a thioacetamide (TAA)-induced HE rat model, focusing on its effects on glial activation and NLRP3 inflammasome signalling.
View Article and Find Full Text PDFUndiagnosed partial ornithine transcarbamylase deficiency presenting as recurrent hyperammonaemic encephalopathy after capecitabine administration.
BMJ Case Rep
January 2025
Internal Medicine, Carolinas Medical Center, Charlotte, North Carolina, USA.
Capecitabine is a widely used drug for cancer treatment. Capecitabine is a derivative of 5-fluorouracil (5-FU). A known complication of 5-FU is hyperammonaemia which can cause encephalopathy.
View Article and Find Full Text PDFCase series report: Equine coronavirus in Australia.
Aust Vet J
December 2024
School of Animal and Veterinary Sciences, University of Adelaide, Roseworthy, South Australia, Australia.
Background: Equine Coronavirus (ECoV) can cause gastrointestinal disease and was first described in 2000 in the USA followed by several international outbreak case reports. Disease manifestation is characterised by vague clinical signs, including mild pyrexia, lethargy and anorexia. Morbidity ranges greatly from 10% to 83%.
View Article and Find Full Text PDFHyperammonaemic encephalopathy due to non-functioning urea cycle as a complication to gastric bypass surgery.
Metab Brain Dis
November 2024
Department of Hepatology and Gastroenterology, Aarhus University Hospital, Palle Juul-Jensens Boulevard, Aarhus, Denmark.
Hyperammonaemic encephalopathy in the absence of liver failure is a major diagnostic challenge. A rare cause is as a complication to previous gastric bypass surgery, a condition reported to be associated with high mortality. In this case report, we present the exhaustive diagnostic work-up and clinical reversal of deep and recurrent hyperammonaemic encephalopathy in a patient with previous gastric bypass surgery.
View Article and Find Full Text PDFSevere non-hepatic hyperammonaemic encephalopathy in an immunocompromised adolescent with enterocolitis.
BMJ Case Rep
June 2024
Critical Care, Dalhousie University, Halifax, Nova Scotia, Canada.
Article Synopsis
- Non-hepatic causes of hyperammonaemia are rare, but a case was reported in an adolescent female with severe aplastic anaemia who developed this condition during treatment.
- She required both intermittent haemodialysis and high-volume continuous veno-venous haemodiafiltration (CVVHDF) to manage the hyperammonaemia, which could not be linked to liver, metabolic, or genetic issues.
- Ultimately, her hyperammonaemia resolved after surgical resection of her inflamed colon, emphasizing the potential of CVVHDF in treating severe cases of hyperammonaemia not related to liver dysfunction.
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