AI Article Synopsis
- Prolonged immobilization of rats for 6 hours daily over 2 weeks significantly reduced oxygen levels and consumption in both gum and bone tissues, indicating compromised periodontal health.
- A decrease of 36% in gum tissue PO2 and a 46% decrease in bone tissue oxygen consumption rate were observed, alongside reduced mitochondrial respiration, especially for NAD-dependent substrates.
- Treatment with Thiotriazolin and Actovegin helped alleviate the negative effects of stress on oxygen balance in both soft and hard periodontal tissues.
Article Abstract
Influence of prolonged immobilization (6 h strict horizontal position of rats in the tight containers daily for 2 weeks) on oxygen tension, oxygen consumption, pro-/antioxidant balance, and energetic metabolism of soft and hard periodontal tissues has been investigated. It was established that prolonged immobilization stress resulted in marked decrease in the gum tissue PO2 (36%) and in the bone tissue oxygen consumption rate (46%) compared to control. It was also determined that prolonged stress led to a reduction in the gum mitochondrial respiration rate. The latter was more expressed in case of the NAD-dependent substrate oxidation than of the FAD- dependent one. It was determined that the prolonged stress results in intensification of peroxide processes and depletion of antioxidant protection of soft tissues of periodontum. It was found that Thiotriazolin and Actovegin have modified and diminished stress-induced disorders in the soft and hard periodontal tissues oxygen homeostasis under prolonged immobilization stress.
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