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Zoledronic Acid Inhibits Lipopolysaccharide-Induced Osteoclastogenesis by Suppressing Macrophage NLRP3-Mediated Autophagy Pathway.
Immun Inflamm Dis
December 2024
School/Hospital of Stomatology, Guizhou Medical University, Guiyang, China.
Introduction: Inflammatory factors leading to bone loss significantly increase the risk of tooth loosening or implantation failure. Zoledronic acid (ZOL) is a widely used medication for effectively inhibiting excessive bone destruction, but its effect on alleviating inflammatory bone loss remains to be elucidated. In this study, we investigated whether ZOL alleviates inflammatory bone resorption through immunomodulatory effect.
View Article and Find Full Text PDFBone-targeted ultrasound-responsive nanobubbles for siRNA delivery to treat osteoporosis in mice.
Biomater Adv
January 2025
Biionix (Bionic Materials, Implants & Interfaces) Cluster, Department of Medicine, University of Central Florida College of Medicine, Orlando, FL 32827, USA; Department of Material Sciences and Engineering, University of Central Florida, Orlando, FL 32816, USA; Biomedical Engineering Program, Department of Mechanical and Aerospace Engineering, University of Central Florida, Orlando, FL 32816, USA. Electronic address:
This project aimed to study the efficacy of a bone-targeted ultrasound-responsive nanobubble (NB) platform to deliver gene-silencing cathepsin K (CTSK) siRNA into the bone for osteoporosis treatment using in vitro and in vivo studies. To this end, characterization of CTSK siRNA loaded NB functionalized with alendronate (NB-CTSK siRNA-AL) was performed using transmission electron microscopy (TEM) imaging, and a release profile was obtained through fluorescent spectroscopy. In vitro studies were conducted by culturing NB-CTSK siRNA-AL with osteoclasts to evaluate siRNA uptake, CTSK expression, and the expression of tartrate-resistant acid phosphatase (TRAP).
View Article and Find Full Text PDFPeri-implant medication-related osteonecrosis of the jaw mimicking endodontic disease in a cancer patient: A case report.
Aust Endod J
December 2024
Department of Oral Medicine, A.C. Camargo Cancer Center, São Paulo, Brazil.
Article Synopsis
- Medication-related osteonecrosis of the jaw (MRONJ) is a serious condition that can lead to severe bone loss, making diagnosis difficult, especially in patients receiving certain cancer treatments.* -
- A case study of a 68-year-old man with liver cancer showed symptoms of jaw pain, yet initial dental exams revealed no obvious issues until deeper investigation indicated MRONJ Stage 2.* -
- After surgical treatment for MRONJ, the patient experienced relief, highlighting the importance of considering MRONJ in patients with jaw pain who are undergoing specific therapies, as well as the need for careful monitoring of dental health in these individuals.*
Diagnosis of periprosthetic loosening of total hip and knee arthroplasty using Gallium-Zoledronate PET/CT.
Arch Orthop Trauma Surg
November 2024
Clinic for Nuclear Medicine, University Hospital of Bonn, Bonn, Germany.
Purpose: Periprosthetic loosening is a major complication after total hip and knee arthroplasty. Early and accurate diagnosis is essential to choose the right therapeutic path and to avoid further complications. The aim of the study was to evaluate the diagnostic performance of Gallium-Zoledronate ([Ga]Ga-DOTA) PET/CT in detecting periprosthetic loosening in total hip (THA) and total knee arthroplasty (TKA).
View Article and Find Full Text PDF3D-Printed-Cryogel-Impregnated Functionalized Scaffold Augments Bone Regeneration in Critical Tibia Fracture in Goat.
Adv Healthc Mater
December 2024
Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, U.P., 208016, India.
Critical-size bone trauma injuries present a significant clinical challenge because of the limited availability of autografts. In this study, a photocurable composite comprising of polycaprolactone, polypropylene fumarate, and nano-hydroxyapatite (nHAP) (P─P─H) is printed, which shows good osteoconduction in a rat model. A cryogel composed of gelatin-nHAP (GH) is developed to incorporate osteogenic components, specifically bone morphogenetic protein-2 (BMP-2) and zoledronic acid (ZA), termed as GH+B+Z, which is investigated for osteoinductive property in a rat model.
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