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Histologic study of the heart and functionally active zones of skeletal muscles of the lower limbs of fetuses and newborns (71 cases) is undertakes to distinguish the factors affecting the viability of the fetus (new-born) and detect the total-system muscle tissue involvement after the general morphogenetic mechanism. The basic criteria of a pathological process caused by capillarotrophic myocardial insufficiency are dystrophy, necrosis, and sclerosis. Various forms of nonspecific prenatal myopathy were detected in the skeletal muscles; they were combined with symptoms of chronic myocardial hypoxia.

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The authors studied biomicroscopic picture of microcirculation in the vessels of bulbar conjunctiva, renal hemodynamics, blood cell metabolism in 50 patients aged 3-12 with renal and ureteral defects. By morphology of the kidneys assessed at aortography, computer renangiography and other tests 2 groups of children were identified: bilateral congenital urological disorder combined with severe advanced dysplasia of the renal tissue and the ureter, low renal function (group 1); light or moderate disorder of renal function, minimal dysplasia of the renal tissue. In children with renal and urinary defects with renal dysfunction there was systemic abnormal microcirculation (group 1) characterized by severe capillarotrophic insufficiency in the form of unusual winding of all the microvessels, formation of vascular loops and balls, narrowing of capillary lumen, etc.

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Capillarotrophic failure of the microhemocirculation system may be due to: a) interchangeable microvessel reduction under long-term organ and tissue ischemia, b) their transformation into the depot vessels under conditions of venous congestion, c) underdevelopment of the interchangeable part of the microcirculatory bed in children born prematurely, d) programmed capillary reduction in aged persons. True capillary deficiency in the microhemocirculation system results in centralization of tissue circulation and reduction of its metabolic efficiency. Such type of circulation we qualify as the phenomenon of microhemodynamics centralization.

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The condition of microcirculation in the region of the joints was studied by means of polarography on oxygen with an oxygen load and thermography on the Soviet high resolution television set "Paduga" in 30 patients with primary deforming osteoarthrosis (PDOA) and 15 practically healthy persons. Different direction shifts in the levels of supply and consumption of oxygen in the periarticular tissues in patients with PDOA were determined, a considerable drop in oxygen supply to the regions of the affected joints being noted. It has been established that thermography is a method of choice for diagnosis of secondary synovitis and other inflammatory affections of the joints.

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